Genetic risk for obesity predicts nucleus accumbens size and responsivity to real-world food cues
Genetic risk for obesity predicts nucleus accumbens size and responsivity to real-world food cues
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DOI：
10.1073/pnas.1605548113
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发表时间：
2017-01-03
影响因子：
11.1
通讯作者：
Gilbert-Diamond, Diane
中科院分区：
文献类型：
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作者：
Rapuano, Kristina M.;Zieselman, Amanda L.;Gilbert-Diamond, Diane
肥胖是一个主要的公共卫生问题，涉及遗传易感性与暴露于环境因素（例如，食品营销）之间的相互作用；然而，将这些因素联系起来并导致不健康饮食的机制尚不清楚。在78名儿童（9-12岁）的样本中使用著名的肥胖风险多态性（FTO rs9939609），我们观察到肥胖风险儿童对伏隔核（NAcc）食品广告的反应比无风险儿童更强烈。同样，肥胖遗传风险较高的儿童表现出更大的NAcc体积。虽然这种多态性的隐性模型最能预测体重和肥胖，但显性模型最能预测NAcc大小和对食物线索的反应。这些发现表明，遗传上有肥胖风险的儿童更倾向于表现出更强烈的奖励信号，这反过来又可能导致以后生活中不健康的饮食行为。
Obesity is a major public health concern that involves an interaction between genetic susceptibility and exposure to environmental cues (e.g., food marketing); however, the mechanisms that link these factors and contribute to unhealthy eating are unclear. Using a well-known obesity risk polymorphism (FTO rs9939609) in a sample of 78 children (ages 9-12 y), we observed that children at risk for obesity exhibited stronger responses to food commercials in the nucleus accumbens (NAcc) than children not at risk. Similarly, children at a higher genetic risk for obesity demonstrated larger NAcc volumes. Although a recessive model of this polymorphism best predicted body mass and adiposity, a dominant model was most predictive of NAcc size and responsivity to food cues. These findings suggest that children genetically at risk for obesity are predisposed to represent reward signals more strongly, which, in turn, may contribute to unhealthy eating behaviors later in life.