Chelerythrine as a fluorescent light-up ligand for an i-motif DNA structure
Chelerythrine as a fluorescent light-up ligand for an i-motif DNA structure
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DOI：
10.1039/d0nj04863a
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发表时间：
2021-01-07
影响因子：
3.3
通讯作者：
Tang, Yalin
中科院分区：
文献类型：
--
作者：
Chen, Hongbo;Sun, Hongxia;Tang, Yalin
本文报道了一种具有i基序结构的荧光发光配体。白屈菜红碱（CHE）可与i-motif结合并显示出荧光强度的显著增加，而对单链（ssDNA）、双链（dsDNA）和G-四链体表现出弱的响应。这一特性使得CHE在无标记荧光传感系统中具有优势。
A fluorescent light-up ligand for an i-motif structure has been reported in this study. Chelerythrine (CHE) could bind to i-motif and show a significant increase in the fluorescence intensity, while exhibiting weak response towards single-stranded (ssDNA), double-stranded (dsDNA), and G-quadruplexes. This feature makes CHE advantageous in the label-free fluorescence sensing systems.