mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.
mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.
复制标题
MDA-7/IL-24：IL-10基因家族的独特成员，促进了以癌为靶向的毒性。
DOI：
10.1016/j.cytogfr.2010.08.004
复制
发表时间：
2010-10
影响因子：
13
通讯作者：
Fisher, Paul B.
中科院分区：
文献类型：
--
作者：
Dash, Rupesh;Bhutia, Sujit K.;Azab, Belal;Su, Zhao-zhong;Quinn, Bridget A.;Kegelmen, Timothy P.;Das, Swadesh K.;Kim, Keetae;Lee, Seok-Geun;Park, Margaret A.;Yacoub, Adly;Rahmani, Mohammed;Emdad, Luni;Dmitriev, Igor P.;Wang, Xiang-Yang;Sarkar, Devanand;Grant, Steven;Dent, Paul;Curiel, David T.;Fisher, Paul B.
黑色素瘤分化相关基因-7/白介素24(MDA-7/IL-24)是IL-10基因家族中唯一的成员，具有几乎普遍存在的肿瘤特异性毒性，对正常细胞或组织无不良影响。通过分化诱导消减杂交(DISH)从人黑色素瘤细胞中克隆出MDA-7/IL-24，并促进内质网(ER)应激，最终导致广泛的人类癌症细胞凋亡或毒性自噬，当在细胞培养、在人肿瘤异种移植小鼠模型体内和在晚期癌症患者的I期临床试验中进行检测时。这种具有治疗活性的细胞因子还通过抑制血管生成，刺激抗肿瘤免疫反应，并使癌细胞对放射、化疗和抗体诱导的杀伤敏感，从而诱导间接的抗肿瘤活性。
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect anti-tumor activity through inhibition of angiogenesis, stimulation of an anti-tumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.
登录
查看更多内容
DOI：
10.1007/s00262-008-0647-6
发表时间：
2009-08
期刊：
Cancer immunology, immunotherapy : CII
影响因子：
--
作者：
Gao P;Sun X;Chen X;Subjeck J;Wang XY
通讯作者：
Wang XY
影响因子：
6.4
作者：
Chada, S;Mhashilkar, AM;Hunt, KK
通讯作者：
Hunt, KK
影响因子：
8.4
作者：
Copier, J.;Dalgleish, A. G.;Hakansson, L.
通讯作者：
Hakansson, L.
影响因子：
5.6
作者：
Emdad, Luni;Lebedeva, Irina V.;Fisher, Paul B.
通讯作者：
Fisher, Paul B.
影响因子：
11.2
作者：
Dash R;Richards JE;Su ZZ;Bhutia SK;Azab B;Rahmani M;Dasmahapatra G;Yacoub A;Dent P;Dmitriev IP;Curiel DT;Grant S;Pellecchia M;Reed JC;Sarkar D;Fisher PB
通讯作者：
Fisher PB