PROGNOSTIC INDICATORS IN THE INITIAL PRESENTATION OF PNEUMOCYSTIS-CARINII PNEUMONIA
PROGNOSTIC INDICATORS IN THE INITIAL PRESENTATION OF PNEUMOCYSTIS-CARINII PNEUMONIA
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DOI：
10.1378/chest.95.4.769
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发表时间：
1989-04-01
期刊：
影响因子：
9.6
通讯作者：
GREENE, J
中科院分区：
文献类型：
--
作者：
GARAY, SM;GREENE, J
我们前瞻性地评估了150例连续的卡氏肺孢子虫肺炎（PCP）患者作为艾滋病的唯一初始表现（组1）。分析了入院实验室和放射学标准的诊断和预后指标，并与非PCP肺部表现的艾滋病患者（第2组）进行比较。平均入院血清LDH水平为465 ± 0.01。PCP患者（第1组）为67 IU/L，第2组为28 IU/L（P < 0.01）。78%的PCP患者（150人中的117人）存活。存活者与死亡者比较，入院时LDH平均值为394 ± 0.05。45比717 .+-. 51 IU/L（p < 0.01），平均P（A-a）O2梯度为42 ± 0.01。6比55 .+-. 6 mm Hg（p < 0.05）。血清LDH水平和P（A-a）O2梯度对AIDS相关PCP患者的诊断和预后有意义。
We prospectively evaluated 150 consecutive patients with Pneumocystis carinii pneumonia (PCP) as their sole inital manifestation of AIDS (group 1). Admission laboratory and radiographic criteria were analyzed for diagnostic and prognostic indicators and compared with those of patients presenting with non-PCP pulmonary manifestations of AIDS (group 2). Mean admission serum LDH level was 465 .+-. 67 IU/L in PCP patients (group 1) and 211 .+-. 28 IU/L in group 2 (p < 0.01). Seventy-eight percent of PCP patients (117 of 150) survived. Comparing survivors with nonsurvivors, the mean admission LDH level was 394 .+-. 45 vs 717 .+-. 51 IU/L (p < 0.01), and the mean P(A-a)O2 gradient was 42 .+-. 6 vs 55 .+-. 6 mm Hg (p < 0.05). Serum LDH levels and P (A-a) O2 gradient have diagnostic and prognostic implications in patients with AIDS-related PCP.