Self-reported snoring is associated with chronic kidney disease in obese but not in normal-weight Chinese adults.
Self-reported snoring is associated with chronic kidney disease in obese but not in normal-weight Chinese adults.
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DOI：
10.1080/0886022x.2021.1915332
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发表时间：
2021-12
期刊：
影响因子：
3
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Jiang Z;Qin J;Liang K;Zhao R;Yan F;Hou X;Wang C;Chen L
睡眠障碍与慢性肾脏疾病（CKD）之间的关系已经有报道。打鼾是阻塞性睡眠呼吸暂停低通气综合征的常见临床表现，对评估睡眠障碍严重程度具有临床价值。然而，关于打鼾和慢性肾病之间关系的调查是有限的，特别是在正常体重人群中。本研究评估了中国肥胖者和正常体重者打鼾频率与慢性肾病的关系。对3250名参与者进行了基于社区的回顾性横断面研究。研究参与者根据自己报告的打呼频率分为三组——经常打呼组、偶尔打呼组和从不打呼组。CKD被定义为肾小球滤过率低于60ml /min/1.73 m2。采用多元logistic回归分析探讨打鼾频率与慢性肾病患病率的相关性。肥胖参与者的CKD患病率高于正常体重参与者。在肥胖组中，频繁打鼾者的CKD患病率高于不频繁打鼾者。肥胖受试者打鼾频率与CKD患病率相关，与年龄、性别、吸烟和饮酒状况、收缩压、甘油三酯水平、高密度脂蛋白和胰岛素抵抗的稳态模型评估无关（优势比：2.66;95% CI: 1.36-5.19; p= 0.004），而正常体重受试者不存在相同的关系（优势比：0.79;95% CI: 0.32-1.98; p= 0.614）。打鼾似乎与肥胖的CKD独立相关，而与正常体重的中国成年人无关。
The relationship between sleeping disorders and chronic kidney disease (CKD) has already been reported. Snoring, a common clinical manifestation of obstructive sleep apnea–hypopnea syndrome, is of clinical value in assessing sleeping disorder severity. However, investigations of the connection between snoring and CKD are limited, especially in normal-weight populations. This study assessed the relationship between snoring frequency and CKD in obese and normal-weight people in China. A community-based retrospective cross-sectional study of 3250 participants was performed. Study participants were divided into three groups – the regularly snoring group, occasionally snoring group, and never snoring group – based on their self-reported snoring frequency. CKD was defined as an estimated glomerular filtration rate of less than 60 mL/min/1.73 m2. Multiple logistic regression analysis was used to explore the relevance between snoring frequency and CKD prevalence. The CKD prevalence in obese participants was higher than that in normal-weight participants. Frequent snorers had a higher prevalence of CKD than those who were not frequent snorers in the obese group. Snoring frequency was correlated with CKD prevalence in obese participants independent of age, sex, smoking and drinking status, systolic blood pressure, triglyceride level, high-density lipoprotein, and homeostasis model assessment of insulin resistance (odds ratio: 2.66; 95% CI: 1.36–5.19; p=.004), while the same relationships did not exist in normal-weight participants (odds ratio: 0.79; 95% CI: 0.32–1.98; p=.614). Snoring appears to be independently associated with CKD in obese but not in normal-weight Chinese adults.