Ionic Liquid-Based Fluorescein Colorimetric pH Nanosensors.
Ionic Liquid-Based Fluorescein Colorimetric pH Nanosensors.
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DOI：
10.1039/c3ra42394h
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发表时间：
2013-11-21
期刊：
影响因子：
3.9
通讯作者：
Warner IM
中科院分区：
文献类型：
--
作者：
Das S;Magut PK;de Rooy SL;Hasan F;Warner IM
报道了一种新型的基于荧光素鏻盐的pH敏感比色离子液体纳米传感器。在此，通过使用三己基十四烷基鏻阳离子[TTP]+与双阴离子[FL]2-和单阴离子[FL]-荧光素的组合来合成各种化学计量的荧光素盐。从这两种化合物衍生的纳米材料在中性和酸性环境中产生了对比鲜明的比色反应。还观察到荧光光谱随pH的变化。TEM和DLS数据的检查揭示了在可变pH的酸性环境中[TTP]2[FL]纳米液滴的直径的显著扩张。对于[TTP][FL]纳米颗粒也观察到类似的趋势。这些纳米材料的pH依赖性比色和其他光学性质归因于分子取向和堆叠的改变，如通过测量吸收、荧光和zeta电位所建议的。由于pH值是许多疾病（包括癌症）的重要指标，因此这些纳米传感器被认为是生物医学应用的潜在候选者。
A novel pH sensitive, colorimetric ionic liquid nanosensor based on phosphonium salts of fluorescein is reported. Herein, fluorescein salts of various stoichiometries were synthesized by use of a trihexyltetradecylphosphonium cation [TTP]+ in combination with dianionic [FL]2− and monoanionic [FL]− fluorescein. Nanomaterials derived from these two compounds yielded contrasting colorimetric responses in neutral and acidic environments. Variations in fluorescence spectra as a function of pH were also observed. Examination of TEM and DLS data revealed significant expansion in the diameter of [TTP]2[FL] nanodroplets in acidic environments of variable pHs. A similar trend was also observed for [TTP][FL] nanoparticles. The pH dependent colorimetric and other optical properties of these nanomaterials are attributed to alterations in molecular orientations and stacking as suggested by measuring the absorption, fluorescence, and zeta potential. Since the pH is an important indicator for many diseases, including cancer, these nanosensors are considered to be potential candidates for biomedical applications.