Malignant lymphoma of the thyroid gland: a clinicopathologic study.
Malignant lymphoma of the thyroid gland: a clinicopathologic study.
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甲状腺恶性淋巴瘤：临床病理学研究。
DOI：
10.1002/hed.2890040403
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
C. Watson
中科院分区：
文献类型：
--
作者：
S. Kapadia;A. Dekker;V. Cheng;Uma Desai;C. Watson
本研究回顾了 1969 年至 1980 年间诊断的 21 例甲状腺淋巴瘤病例。除两例外，所有病例的原发部位均是甲状腺。 20 名非霍奇金淋巴瘤患者平均年龄 66 岁，75% 为女性，且均为白人。最初发现甲状腺肿块迅速增大，伴有声音嘶哑、吞咽困难和呼吸困难。大多数患者患有弥漫性组织细胞淋巴瘤。 57% 的病例在组织学上发现相关桥本甲状腺炎。采用免疫过氧化物酶染色法对组织切片进行检测，15例中有5例发现胞浆内单克隆免疫球蛋白。除两名患者外，所有患者均接受了放射治疗，13 名患者接受了化疗。中位生存期为 8 个月； 20% 的人死于无关原因，32% 的人还活着（平均持续时间：27 个月）。通过放射治疗进行局部控制后的传播是死亡的主要原因。男性、65 岁以下患者以及活检未发现甲状腺外软组织或区域淋巴结受累的患者的预后较好。
This study reviews 21 cases of thyroid lymphoma diagnosed between 1969 and 1980. The thyroid gland was the primary site in all but two cases. The 20 patients with non-Hodgkin lymphoma had a mean age of 66 years, 75% were women, and all were Caucasian. A rapidly growing thyroid mass with hoarseness, dysphagia, and difficulty in breathing was the initial finding. Most patients had diffuse histiocytic lymphomas. Associated Hashimoto thyroiditis was found histologically in 57% of the cases. Using the immunoperoxidase stain method on tissue sections, intracytoplasmic monoclonal immunoglobulin was demonstrated in 5 of 15 cases. All but two patients received radiation therapy, and 13 received chemotherapy. The median survival was 8 months; 20% died of unrelated causes and 32% are alive (average duration: 27 months). Dissemination, after local control by radiation therapy, was the leading cause of death. The prognosis was better in men, in patients under the age of 65 years, and in those patients who, on biopsy, did not have involvement of the extrathyroid soft tissue or regional lymph nodes.
影响因子：
11.2
作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
通讯作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana