Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease
Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease
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DOI：
10.1016/j.brainres.2005.11.021
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发表时间：
2006-01-19
期刊：
影响因子：
2.9
通讯作者：
Gruys, E
中科院分区：
文献类型：
--
作者：
Rofina, JE;van Ederen, AM;Gruys, E
在老年犬中，经常观察到类似阿尔茨海默病的行为。几位作者使用问卷对这种行为进行了分类，并描述了认知功能障碍和阿尔茨海默样病理之间的相关性。在本研究中，30 只不同年龄的狗的认知表现与大脑病理学相关。在这些动物中，比较了两组年龄匹配的有或没有行为变化的老狗。通过问卷对行为变化进行分析和评分，并进行尸检以排除行为变化的任何其他原因。使用测量、（免疫）组织化学染色和荧光显微镜来检测这些狗大脑中的皮质萎缩、淀粉样蛋白、氧化损伤的剩余产物、脱髓鞘和巨噬细胞的积累。 Spearman等级相关系数(r)根据Bonferonni计算和调整。在整个组中（从年轻到年老的狗），动物的年龄与各种行为变化显着相关（r = 0.7 至 0.9，P < 0.01）。痴呆评分与所研究的所有脑部病变均显着相关（r = 0.6 至 0.8，P < 0.01），但脱髓鞘除外。 （r = -0.4，P > 0.05）。这些结果表明，问卷可用于诊断犬类实践中的阿尔茨海默样变化。细胞和核水平的氧化损伤在行为改变中起着重要作用。 (c) 2005 Elsevier B.V. 保留所有权利。
In geriatric dogs, Alzheimer-like behavior is frequently observed. This behavior has been classified by several authors using questionnaires and a correlation has been described between cognitive dysfunctions and Alzheimer-like pathology. In the present study, cognitive performance was correlated with brain pathology for 30 dogs of varying ages. Within these animals, two age-matched groups of old dogs with and without behavioral changes were compared. The behavioral changes were analyzed and scored with questionnaires and necropsy was performed to rule out any other cause for changed behavior. Measurements, (immuno)-histochemical staining and fluorescence microscopy were used to detect cortex atrophy, amyloid, rest-products of oxidative damage, demyelination and accumulations of macrophages in the brains of these dogs. Spearman rank correlation coefficients (r) were calculated and adjusted according to Bonferonni. In the whole group (young to very old dogs), the age of the animal showed a significant correlation with various behavioral changes (r = 0.7 to 0.9, P < 0.01). The dementia score correlated significantly (r = 0.6 to 0.8, P < 0.01) with all the brain lesions studied, except one, i.e. demyelination. (r = -0.4, P > 0.05). These results suggest that a questionnaire can be used to diagnose Alzheimer-like changes in canine practice. Oxidative damage on a cellular and a nuclear level plays an important role in behavior changes. (c) 2005 Elsevier B.V. All rights reserved.