Vitamin E revisited: do new data validate benefits for chronic disease prevention?
Vitamin E revisited: do new data validate benefits for chronic disease prevention?
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重新审视维生素 E：新数据是否验证了对慢性病预防的益处？
DOI：
10.1097/mol.0b013e3282f2dab6
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发表时间：
2008
影响因子：
4.4
通讯作者：
Beckman,JosephS
中科院分区：
文献类型：
--
作者：
Traber,MaretG;Frei,Balz;Beckman,JosephS
α-生育酚在脂质环境中作为过氧基和烷氧基的清除剂，从而防止脂蛋白和膜，特别是神经组织中的脂质过氧化。慢性病发病率的降低与终生摄入大量的维生素E有关，但超过90%的美国人没有摄入推荐的膳食量(每天15毫克)。维生素E补充剂除了对饮食有好处外，还可以对健康产生有益的影响，可能是因为药物水平也上调了肝脏异种生物的途径。
α-Tocopherol acts as a peroxyl and alkoxyl radical scavenger in lipid environments, and thus it prevents lipid peroxidation in lipoproteins and membranes, especially nervous tissues. Decreased chronic disease incidence is associated with lifelong generous dietary vitamin E intakes, but more than 90% of Americans do not consume the recommended dietary amounts (15 mg/day). Vitamin E supplements can have beneficial effects on health beyond those from dietary amounts, perhaps because pharmacologic levels also upregulate hepatic xenobiotic pathways.