F2 isoprostane is already increased at the onset of type 1 diabetes mellitus:: Effect of glycemic control
F2 isoprostane is already increased at the onset of type 1 diabetes mellitus:: Effect of glycemic control
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DOI：
10.1016/j.metabol.2004.04.005
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发表时间：
2004-09-01
影响因子：
9.8
通讯作者：
Esmatjes, E
中科院分区：
文献类型：
--
作者：
Flores, L;Rodela, S;Esmatjes, E
大量证据表明，氧化应激（OS）可能在糖尿病并发症的发病机制中发挥作用。然而，在糖尿病临床研究中，高血糖与OS之间的关系并不一致。本研究的目的是评估1型糖尿病发病时血糖水平正常化对尿8-表-前列腺素F-2 α（8-epi-PGF（2 α））排泄的影响。我们研究了14例1型糖尿病患者（50%为男性;平均年龄24.3 ± 4.9岁）和14例年龄和体重指数匹配的对照组。在基线、开始胰岛素治疗前和治疗16周后采集24小时尿液，测定8-epi-PGF（2 α）作为OS产生的综合指数。第16周，胰岛素治疗诱导糖化血红蛋白（HbA（1c））（从11.5%降至5.4%，P = 0.0001）、甘油三酯（从1.0降至0.8 mmol/L，P = 0.002）显著降低，高密度脂蛋白（HDL）-胆固醇水平升高（从1.1至1.5 nmol/L，P = 0.01）。代谢控制的改善与8-epi-PGF（2 α）值的统计学显著降低相关（从92.0 +/- 41.5到66.9 +/- 28.9 pg/mg尿肌酐排泄，P = 0.015），尽管与对照组相比，糖尿病患者的8-epi-PGF（2 α）值仍然较高（66.9 +/- 28.9 vs 39.1 +/- 13.8 pg/mg肌酐，P = 0.004）。1型糖尿病的早期临床阶段存在OS增强，代谢控制的改善与该致病途径的改善相关。(C)2004爱思唯尔公司All rights reserved.
Much evidence has suggested that oxidative stress (OS) may play a role in the pathogenesis of diabetic complications. However, the relationship between hyperglycemia and OS is inconsistent in diabetic clinical studies. The aim of this study was to evaluate the effect of normalization of blood glucose levels on urinary 8-epi-prostaglandin F-2alpha (8-epi-PGF(2alpha)) excretion at the onset of type 1 diabetes. We studied 14 type 1 diabetic patients (50% males; mean age, 24.3 +/- 4.9 years) and 14 control subjects matched by age and body mass index. A 24-hour urine collection was performed to determine 8-epi-PGF(2alpha) as an integrated index of OS production at baseline, before starting insulin therapy, and 16 weeks later. Insulin treatment induced a significant reduction in glycosylated hemoglobin (HbA(1c)) (from 11.5% to 5.4% P = .0001), triglycerides (from 1.0 to 0.8 mmol/L, P = .002), and an increase in high-density lipoprotein (HDL)-cholesterol levels (from 1.1 to 1.5 nmol/L, P = .01) at week 16. This improvement in metabolic control was associated with a statistically significant reduction in 8-epi-PGF(2alpha) values (from 92.0 +/- 41.5 to 66.9 +/- 28.9 pg/mg urinary reatinine excretion, P = .015), although compared with the control group, 8-epi-PGF(2alpha) values remained higher in diabetic patients (66.9 +/- 28.9 v 39.1 +/- 13.8 pg/mg creatinine, P = .004). Enhanced OS is present in early clinical phases of type 1 diabetes, and the amelioration in metabolic control is associated with improvement in this pathogenic pathway. (C) 2004 Elsevier Inc. All rights reserved.