The origins of protein phosphorylation
The origins of protein phosphorylation
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DOI：
10.1038/ncb0502-e127
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发表时间：
2002-05-01
影响因子：
21.3
通讯作者：
Cohen, P
中科院分区：
文献类型：
--
作者：
Cohen, P
蛋白质的可逆磷酸化对于细胞功能大多数方面的调节至关重要，但是，即使在第一种蛋白激酶被发现之后，这一发现的普遍重要性也迟迟未得到重视。在此，我回顾蛋白质磷酸化的发现，并就那些有助于塑造我们今天所熟知的这一领域的关键发现给出个人观点。
The reversible phosphorylation of proteins is central to the regulation of most aspects of cell function but, even after the first protein kinase was identified, the general significance of this discovery was slow to be appreciated. Here I review the discovery of protein phosphorylation and give a personal view of the key findings that have helped to shape the field as we know it today.