Are hydroxychloroquine and chloroquine effective in the treatment of SARS-COV-2 (COVID-19)?
Are hydroxychloroquine and chloroquine effective in the treatment of SARS-COV-2 (COVID-19)?
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DOI：
10.1038/s41432-020-0098-2
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发表时间：
2020-06-01
影响因子：
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通讯作者：
Mc Goldrick, Niall
中科院分区：
文献类型：
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作者：
Wright, Christopher;Ross, Carly;Mc Goldrick, Niall
数据来源本快速综述的作者没有透露他们的文献检索包括哪些电子数据库。研究选择作者纳入了6项关于羟氯喹或氯喹在人类中预防和治疗COVID-19的有效性的研究。研究包括两项随机对照试验、两项非随机试验（均为非盲和开放标签）和一项非对照试验、一项前瞻性队列研究和一份中期报告。数据提取和综合数据提取方法没有报告，目前还不清楚是否遵循了系统性综述和荟萃分析的首选报告项目（PRISMA）指南。提取可用的治疗方案和研究结局，并在表格中列出总体结果。没有可比的结局指标;因此，认为结果不适合合并联合收割机，未进行统计分析。每个研究的叙述性合成presented.Results在这个快速审查的研究结果是难以量化的，因为每个研究有不同的结果参数。由于研究的异质性，未合并结果，也未进行统计分析。每个纳入的研究的叙述性综合确定了重要的和显著的局限性，排除了研究显示的统计学显著差异outcome.Conclusions使用羟氯喹和氯喹在预防和治疗COVID-19的迫切需要更多的高质量的证据。由于支持性数据薄弱和许多方法学限制，应谨慎解释所纳入研究的结果。作者建议，这些研究应被视为假设生成，不应用于围绕预防和治疗COVID-19的建议和指南的决策。目前有几项正在进行的随机对照试验正在研究这些药物对COVID-19的有效性和疗效。希望这些研究的结果能够帮助指导今后的建议和国家准则。
Data sources The authors of this rapid review did not disclose which electronic databases were included in their literature search. The inclusion and exclusion criteria for the data sources are not reported in the manuscript.Study selection The authors included six studies on the effectiveness of hydroxychloroquine or chloroquine for the prevention and treatment of COVID-19 in humans. Studies comprised of two randomised controlled trials, two non-randomised trials both of which were non-blinded and open-label and one that was uncontrolled, a prospective cohort study and an interim report. The authors did not report details of any studies that were excluded.Data extraction and synthesis The data extraction methodology was not reported and it is unclear if the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed. Treatment regimens and the study outcomes were extracted where available and overall findings were presented in a table. There were no comparable outcome measures; therefore, results were deemed unsuitable to combine and no statistical analyses were carried out. A narrative synthesis of each study is presented.Results The results of the studies in this rapid review are difficult to quantify as each study had different outcome parameters. Due to the heterogeneity of the studies, results were not combined, and no statistical analysis was carried out. Narrative synthesis of each of the included studies identified important and significant limitations, precluding the studies from demonstrating a statistically significant difference in outcomes.Conclusions This review highlights the urgent need for more high quality evidence on the use of hydroxychloroquine and chloroquine in the prevention and treatment of COVID-19. The results of the studies included should be interpreted with caution due to the weak supporting data and numerous methodological limitations. The authors suggested that the studies be viewed as hypothesis-generating and should not be used in decision making around the recommendations and guidelines in the prevention and treatment of COVID-19. There are currently several ongoing randomised controlled trials looking at the effectiveness and efficacy of these drugs on COVID-19. It is hoped the outcome of these studies can help guide future recommendations and national guidelines.