MODULATORY EFFECT OF PLUMBAGIN (5-HYDROXY-2-METHYL-1,4-NAPHTHOQUINONE) ON MACROPHAGE FUNCTIONS IN BALB/C MICE .1. POTENTIATION OF MACROPHAGE BACTERICIDAL ACTIVITY
MODULATORY EFFECT OF PLUMBAGIN (5-HYDROXY-2-METHYL-1,4-NAPHTHOQUINONE) ON MACROPHAGE FUNCTIONS IN BALB/C MICE .1. POTENTIATION OF MACROPHAGE BACTERICIDAL ACTIVITY
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DOI：
10.1016/0162-3109(95)00027-q
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发表时间：
1995-09-01
期刊：
影响因子：
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通讯作者：
RAMCHENDER, RP
中科院分区：
文献类型：
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作者：
ABDUL, KM;RAMCHENDER, RP
本文研究了白桦白桦素对BALB/c小鼠腹腔巨噬细胞的调节作用。评估巨噬细胞的功能包括杀菌活性、过氧化氢和超氧阴离子释放。测定了经铅白金处理的小鼠巨噬细胞对金黄色葡萄球菌的杀灭能力。在整个研究期间，低剂量白桦素的杀菌活性不断增加，而在高剂量下，在长达六周的时间内观察到更高的反应。但在接下来的两周内，与低剂量相比，杀菌活性明显下降。在体内还观察到白莲苷对巨噬细胞释放氧自由基有类似的作用，表明氧自由基释放与杀菌活性有明显的相关性。结果表明，水蛭素在低浓度时通过促进氧自由基的释放来增强巨噬细胞的杀菌活性，而在高浓度时则具有抑制活性。
The modulatory ability of plumbagin, a natural product from Plumbago zeylanica, was studied on peritoneal macrophages of BALB/c mice. The macrophage functions evaluated were bactericidal activity, hydrogen peroxide and superoxide anion release. The bactericidal capacity of in vivo plumbagin-treated mouse macrophages was estimated against Staphylococcus aureus. In low doses plumbagin exerted a constant increase in bactericidal activity throughout the study period whereas with a high dose a higher response was observed up to six weeks. But in the next two weeks a considerable decline in the bactericidal activity was noticed compared to low dose. Plumbagin was also seen to exert a similar response on oxygen radical release by macrophages in vivo showing a clear correlation between oxygen radical release and the bactericidal activity. The data indicate that plumbagin augments the macrophage bactericidal activity by potentiating the oxyradical release at low concentration whereas at the higher concentration it has inhibitory activity.