Characterization of the 3D microstructure of Ibuprofen tablets by means of synchrotron tomography
Characterization of the 3D microstructure of Ibuprofen tablets by means of synchrotron tomography
复制标题
DOI：
10.1111/jmi.12789
复制
发表时间：
2019-05-01
影响因子：
2
通讯作者：
Schmidt, Volker
中科院分区：
文献类型：
--
作者：
Neumann, Matthias;Cabiscol, Ramon;Schmidt, Volker
提出了一种利用同步加速器断层扫描对布洛芬片三维内部结构进行分割的新方法，对布洛芬片由微晶纤维素、布洛芬和孔隙三个相组成的灰度图像进行物理相干三分化。为此，提出了一种结合统计学习的三化和基于分水岭算法的三化的混合方法。这种混合方法允许我们使用统计图像分析的方法来计算片剂的微观结构特征。与实验结果的对比表明，存在大量低于分辨率极限的孔隙。同时，从图像分析的结果可以推测，这些孔隙构成了孔隙与固体之间的绝大部分表面。此外，我们还计算了实验无法获得的微观结构特征，如局部渗透概率和弦长分布函数。这两个特征对于量化压实对其微观结构的影响是有意义的。基于不同工艺条件下生产的布洛芬片的三维图像数据，该方法可以更好地了解生产参数与微观结构特征之间的关系，并阐明影响最终制剂强度和溶解度动力学的关键因素。
A new methodology to segment the three-dimensional (3D) internal structure of Ibuprofen tablets from synchrotron tomography is presented, introducing a physically coherent trinarization for greyscale images of Ibuprofen tablets consisting of three phases: microcrystalline cellulose, Ibuprofen and pores. For this purpose, a hybrid approach is developed combining a trinarization by means of statistical learning with a trinarization based on a watershed algorithm. This hybrid approach allows us to compute microstructure characteristics of tablets using methods of statistical image analysis. A comparison with experimental results shows that there is a significant amount of pores which is below the resolution limit. At the same time, results from image analysis let us conjecture that these pores constitute the great majority of the surface between pores and solid. Furthermore, we compute microstructure characteristics, which are experimentally not accessible such as local percolation probabilities and chord length distribution functions. Both characteristics are meaningful in order to quantify the influence of tablet compaction on its microstructure. The presented approach can be used to get better insight into the relationship between production parameters and microstructure characteristics based on 3D image data of Ibuprofen tablets manufactured under different conditions and elucidate key effects on the strength and solubility kinetics of the final formulation.