A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS).
A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS).
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DOI：
10.1017/s1368980013002565
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发表时间：
2014-08
影响因子：
3.2
通讯作者：
Hebert, James R.
中科院分区：
文献类型：
--
作者：
Shivappa, Nitin;Steck, Susan E.;Hurley, Thomas G.;Hussey, James R.;Ma, Yunsheng;Ockene, Ira S.;Tabung, Fred;Hebert, James R.
使用来自两种不同膳食评估的膳食数据和血清高敏C反应蛋白（hs-CRP）作为构建验证器，对基于人群的膳食炎症指数（DII）进行构建验证。使用的数据来自（i）基线和随后每个季度末的三次24小时饮食回忆（24 HR）（即一年内最多15次）和（ii）在基线时测量的7天饮食回忆（7 DDR），然后每季度进行回归分析，以检验DII评分对血清hs-CRP的影响，（≤ 3 mg/l，> 3 mg/l），同时控制重要的潜在混杂因素。来自血胆固醇季节性变化研究（SEASONS）的现有数据，这是一项在美国马萨诸塞州伍斯特招募的健康受试者的纵向观察性研究，对受试者进行了1年的随访。在1年参与期间至少有一次hs-CRP测量的参与者（24 HR n 495，7 DDR n 559）。DII评分较高与hs-CRP >3 mg/l相关（24 HR的OR = 1.08; 95%CI 1.01，1.16，P = 0.035; 7 DDR的OR = 1.10; 95%CI 1.02，1.19，P = 0.015）。基于人群的DII与使用24 HR和7 DDR的hs-CRP的间期变化相关。这种首次尝试使用这种改进的DII将个体的炎症调节食物摄入量联系起来的成功，以及使用结构化问卷与24 HR标准相比预测能力几乎没有下降的发现，为DII在各种其他流行病学和临床研究中的使用奠定了基础。
To perform construct validation of the population-based Dietary Inflammatory Index (DII) using dietary data from two different dietary assessments and serum high-sensitivity C-reactive protein (hs-CRP) as the construct validator. Using data derived from (i) three 24 h dietary recalls (24HR) at baseline and at the end of each subsequent quarter (i.e. up to fifteen over a year) and (ii) a 7 d dietary recall (7DDR) measured at baseline and then quarterly, regression analyses were conducted to test the effect of the DII score on serum hs-CRP as dichotomous (≤3mg/l, >3mg/l), while controlling for important potential confounders. Existing data from the Seasonal Variation of Blood Cholesterol Study (SEASONS), a longitudinal observational study of healthy participants recruited in Worcester, MA, USA and participants were followed for 1 year. Participants who had at least one hs-CRP measurement over her/his 1-year participation (n 495 for 24HR, n 559 for 7DDR). Higher DII scores were associated with values of hs-CRP >3 mg/l (OR = 1·08; 95% CI 1·01, 1·16, P = 0·035 for the 24HR; and OR = 1·10; 95% CI 1·02, 1·19, P = 0·015 for the 7DDR). The population-based DII was associated with interval changes in hs-CRP using both the 24HR and 7DDR. The success of this first-of-a-kind attempt at relating individuals’ intakes of inflammation-modulating foods using this refined DII, and the finding that there is virtually no drop-off in predictive capability using a structured questionnaire in comparison to the 24HR standard, sets the stage for use of the DII in a wide variety of other epidemiological and clinical studies.