Antioxidant activities of extracts and flavonoid compounds from Oxytropis falcate Bunge
Antioxidant activities of extracts and flavonoid compounds from Oxytropis falcate Bunge
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DOI：
10.1080/14786410701875686
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发表时间：
2008-01-01
影响因子：
2.2
通讯作者：
Jiang, S. X.
中科院分区：
文献类型：
--
作者：
Jiang, H.;Zhan, W. Q.;Jiang, S. X.
采用1，1-二苯基-2-苦肼基（DPPH）自由基清除法研究镰形棘豆不同提取物和黄酮类化合物的抗氧化性能。在氯仿、乙酸乙酯和正丁醇提取物中，乙酸乙酯提取物的抗氧化活性最高（IC_（50）= 2.05 mg·mL ~（-1））。此外，从氯仿和乙酸乙酯提取物中纯化了鼠李柠檬素、山奈酚、鼠李素、2 '，4'-二羟基查耳酮和2 '，4'，β-三羟基-二氢查耳酮。结果表明，山奈酚（IC 50 = 0.11 mg mL（-1））、鼠李素（IC 50 = 0.14 mg mL（-1））和鼠李柠檬素（IC 50 = 0.15 mg mL（-1））具有较好的抗氧化活性，而二氢查耳酮的抗氧化活性很弱。虽然这些类黄酮是已知的，但这是首次报道这种植物的抗氧化活性。
The antioxidant properties of the various extracts and flavonoids prepared from Oxytropis falcate Bunge were investigated by 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. In the chloroform, ethyl acetate and n-butanol extracts, the ethyl acetate extract exhibited the highest antioxidant activity (IC50 = 2.05 mg mL(-1)). Furthermore, rhamnocitrin, kaempferol, rhamnetin, 2',4'-dihydroxychalcone and 2',4', beta-trihydroxy-dihydrochalcone were purified from chloroform and ethyl acetate extracts. The radical-scavenging activities of the five compounds were also measured and the results showed that kaempferol (IC50 = 0.11 mg mL(-1)), rhamnetin (IC50 = 0.14 mg mL(-1)) and rhamnocitrin (IC50 = 0.15 mg mL(-1)) exhibited considerable antioxidant activities, but the antioxidant activities of the two dihydrochalcones were very weak. Although these flavonoids are known, this is the first report of antioxidant activity in this plant.