Antioxidant phenolic compounds from the rhizomes of Astilbe rivularis
Antioxidant phenolic compounds from the rhizomes of Astilbe rivularis
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DOI：
10.1080/14786419.2017.1309536
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发表时间：
2018-01-01
影响因子：
2.2
通讯作者：
Devkota, Hari Prasad
中科院分区：
文献类型：
--
作者：
Hori, Kengo;Wada, Mikiyo;Devkota, Hari Prasad
落新妇的根茎，通常被称为Thulo Okhati'，在尼泊尔被广泛用作子宫和月经失调的补品。在我们的初步研究中，根茎的70%MeOH提取物显示出有效的抗氧化活性。因此，本研究旨在分离有效的抗氧化成分。从其根茎中分得岩白菜素（1）、11-O-没食子酰岩白菜素（2）、（+）-儿茶素（3）、（-）-儿茶素（4）、（-）-阿夫泽莱辛（5）、（-）-表阿夫泽莱辛（6）和2-（-D-吡喃葡萄糖氧基）-4-羟基苯乙腈（7）。利用波谱方法鉴定了化合物的结构。采用DPPH自由基清除实验对所有化合物的体外抗氧化活性进行了评价。11-O-没食子酰岩白菜素（2）、（+）-儿茶素（3）、（-）-儿茶素（4）、（-）-阿夫泽莱欣（5）和（-）-表阿夫泽莱欣（6）具有较强的抗氧化活性。[图形]。
The rhizomes of Astilbe rivularis, commonly known as Thulo Okhati' are widely used in Nepal as tonic for uterine and menstrual disorders. In our preliminary study, the 70% MeOH extract of the rhizomes showed potent antioxidant activity. Hence, present study was aimed for the isolation of potent antioxidant constituents. Bergenin (1), 11-O-galloylbergenin (2), (+)-catechin (3), (-)-catechin (4), (-)-afzelechin (5), (-)-epiafzelechin (6) and 2-(-D-glucopyranosyloxy)-4-hydroxylbenzenacetonitrile (7) were isolated from the rhizomes. Structures of these compounds were elucidated on the basis of spectroscopic methods. All these isolated compounds were evaluated for their in vitro antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. 11-O-Galloylbergenin (2), (+)-catechin (3), (-)-catechin (4), (-)-afzelechin (5) and (-)-epiafzelechin (6) showed potent antioxidant activity.[GRAPHICS].