TELOMERES AND TELOMERASE IN AGING AND CANCER
TELOMERES AND TELOMERASE IN AGING AND CANCER
复制标题
DOI：
10.1016/0959-437x(95)80016-6
复制
发表时间：
1995-04-01
影响因子：
4
通讯作者：
VILLEPONTEAU, B
中科院分区：
文献类型：
--
作者：
HARLEY, CB;VILLEPONTEAU, B
端粒由新型核糖核蛋白端粒酶维持。大多数人体细胞中端粒酶活性受到抑制，导致体内和体外复制衰老过程中端粒丢失。然而，端粒酶似乎在几乎所有人类癌症中都会重新激活。随着最近从几个物种中克隆出端粒酶的RNA成分，现在已经为端粒和端粒酶在衰老和癌症中的作用进行关键测试做好了准备。
Telomeres are maintained by the novel ribonucleoprotein enzyme telomerase. Telomerase activity is repressed in most somatic human cells, leading to telomere loss during replicative aging in-vivo and in vitro. However, telomerase appears to be reactivated in essentially all human cancers. With the recent cloning of the RNA component of telomerase from several species, the stage is now set for critical tests of the role of telomeres and telomerase in aging and cancer.