Ghrelin and cardiovascular diseases.
Ghrelin and cardiovascular diseases.
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DOI：
10.2174/157340310790231662
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发表时间：
2010-02
影响因子：
1.9
通讯作者：
Tang C
中科院分区：
文献类型：
--
作者：
Zhang G;Yin X;Qi Y;Pendyala L;Chen J;Hou D;Tang C
Ghrelin是一种新发现的生物活性多肽，是生长激素(GH)促分泌素受体的天然内源性配体，最初被认为是GH释放的强刺激剂。后来的研究表明，Ghrelin及其各种受体在许多其他器官和组织中普遍存在。此外，它们还参与食欲、能量、体重、糖和脂肪代谢的调节，以及胃肠、心血管、肺、免疫功能和细胞增殖/凋亡的调节。越来越多的证据表明，Ghrelin与心血管系统关系密切。Ghrelin及其受体广泛分布于心血管组织中，毫无疑问，Ghrelin在心血管系统中的作用不仅通过其生长激素释放作用，而且还通过其对心脏的直接作用而介导。外源性应用Ghrelin可扩张外周血管，收缩冠状动脉，改善内皮功能，抑制心肌细胞凋亡。因此，Ghrelin可能具有心血管保护作用，包括降低血压、调节动脉粥样硬化、保护缺血/再灌注损伤以及改善心肌梗死和心力衰竭的预后。其中一些Ghrelin的新功能可能为Ghrelin在心血管医学中提供新的潜在治疗机会。本文综述了Ghrelin心血管作用的现有证据，包括心血管功能、Ghrelin血浆水平在病理生理条件下的变化、Ghrelin可能的保护机制以及其潜在的治疗作用。
Ghrelin, a newly discovered bioactive peptide, is a natural endogenous ligand of the growth hormone (GH) secretagogue receptor and initially identified as a strong stimulant for the release of GH. Subsequent research has shown that ghrelin and its various receptors are ubiquitous in many other organs and tissues. Moreover, they participate in the regulation of appetite, energy, bodyweight, metabolism of glucose and fat, as well as modulation of gastrointestinal, cardiovascular, pulmonary, immune functions and cell proliferation/apoptosis. Increasing evidence has demonstrated that ghrelin has a close relationship with cardiovascular system. Ghrelin and its receptors are widely distributed in cardiovascular tissues, and there is no doubt that the effects of ghrelin in the cardiovascular system are mediated not only via its growth-hormone-releasing effect but also by its direct effects on the heart. Exogenous administration of ghrelin can dilate peripheral blood vessels, constrict coronary artery, improve endothelial function, as well as inhibit myocardial cell apoptosis. So, ghrelin may have cardiovascular protective effect, including lowering of blood pressure, regulation of atherosclerosis, and protection from ischemia/reperfusion injury as well as improving the prognosis of myocardial infarction and heart failure. Some of these new functions of ghrelin may provide new potential therapeutic opportunities for ghrelin in cardiovascular medicine. In this paper, we will review the existing evidence for cardiovascular effects of ghrelin, including the cardiovascular function, the variations in ghrelin plasma levels in pathophysiologicalogical conditions, the possible protective mechanisms of ghrelin, as well as its future potential therapeutic roles.