Is COVID-19-Induced Platelet Activation a Cause of Concern for Patients with Cancer?
Is COVID-19-Induced Platelet Activation a Cause of Concern for Patients with Cancer?
复制标题
新冠肺炎诱导的血小板活化是癌症患者关注的原因吗？
DOI：
10.1158/0008-5472.can-20-3691
复制
发表时间：
2021-03-01
期刊：
影响因子：
11.2
通讯作者：
Vijayan KV
中科院分区：
文献类型：
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作者：
Lichtenberger LM;Vijayan KV
癌症患者更容易感染SARS-CoV-2，并出现严重的后果，包括ICU入院，机械呼吸机支持和高死亡率。与中晚期癌症一样，SARS-CoV-2感染与血小板过度活跃、全身性炎症、血栓形成并发症和凝血功能障碍有关。血小板还促进癌细胞生长、循环中的存活和转移部位的血管生成。在这篇文章中，我们将讨论血小板在SARS-CoV-2感染的癌症患者中发生全身性炎症和血栓形成的可能性，并关注血小板诱导的致病事件可能在COVID-19癌症患者中被放大。
Cancer patients are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associated with platelet hyperactivity, systemic inflammation, thrombotic complications, and coagulopathy. Platelets also promote cancer cell growth, survival in circulation, and angiogenesis at sites of metastases. In this article, we will discuss the potential for platelets in the development of systemic inflammation and thrombosis in SARS-CoV-2 infected cancer patients, with the concern that the platelet-induced pathogenic events are likely magnified in cancer patients with COVID-19.