Effects of a perilymphatic fistula on the passive vibration response of the basilar membrane
Effects of a perilymphatic fistula on the passive vibration response of the basilar membrane
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DOI：
10.1016/j.heares.2011.10.006
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发表时间：
2012-01-01
期刊：
影响因子：
2.8
通讯作者：
Ogawa, Kaoru
中科院分区：
文献类型：
--
作者：
Koike, Takuji;Sakamoto, Chiaki;Ogawa, Kaoru
本研究建立了被动式人耳蜗的三维有限元模型。考虑耳蜗液与镫骨踏板的流固耦合作用，分析了镫骨踏板振动引起基底膜的动力特性。接下来，通过在耳蜗模型壁上开一个小孔来检测淋巴周围瘘管（PLF）对耳蜗振动的影响。即使前庭阶梯内存在PLF，基底膜上也会产生行波。当耳蜗基底端存在PLF时，行波包络的形状变化不明显，但在0.5 ~ 5 kHz的整个频率范围内，最大振幅变小，且随频率的降低而减小。与此相反，当第二轮耳蜗存在PLF时，行波包络在PLF位置出现一个缺口，最大振幅也变小。该模型有助于从动力学角度阐明PLF导致听力损失的机制。(C) 2011 Elsevier B.V.版权所有
In this study, a three-dimensional finite-element model of the passive human cochlea was created. Dynamic behavior of the basilar membrane caused by the vibration of the stapes footplate was analyzed considering a fluid-structure interaction with the cochlear fluid. Next, the effects of a perilymphatic fistula (PLF) on the vibration of the cochlea were examined by making a small hole on the wall of the cochlea model. Even if a PLF existed in the scala vestibuli, a traveling wave was generated on the basilar membrane. When a PLF existed at the basal end of the cochlea, the shape of the traveling wave envelope showed no remarkable change, but the maximum amplitude became smaller at the entire frequency range from 0.5 to 5 kHz and decreased with decreasing frequency. in contrast, when a PLF existed at the second turn of the cochlea, the traveling wave envelope showed a notch at the position of the PLF and the maximum amplitude also became smaller. This model assists in elucidating the mechanisms of hearing loss due to a PLF from the view of dynamics. (C) 2011 Elsevier B.V. All rights reserved.