A comparison between the soluble transferrin receptor, transferrin saturation and serum ferritin as markers of iron state in hemodialysis patients
A comparison between the soluble transferrin receptor, transferrin saturation and serum ferritin as markers of iron state in hemodialysis patients
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DOI：
10.1159/000064468
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发表时间：
2002-09-01
期刊：
影响因子：
2.5
通讯作者：
Leunissen, KML
中科院分区：
文献类型：
--
作者：
Beerenhout, C;Bekers, O;Leunissen, KML
充足的铁管理对于贫血治疗和血液透析 (HD) 患者非常重要。血清铁蛋白和转铁蛋白饱和度 (TS) 可能会受到炎症存在的影响。最近，可溶性转铁蛋白受体（s-TfR）被提倡作为 HD 患者铁状态的参数。本研究的目的首先是评估 HD 患者血清铁蛋白、TS 和 s-TfR 之间的关系，并预测它们在缺铁诊断中的一致性（通过 kappa 评估），其次评估炎症对铁状态参数之间关系的影响。任一标志物的缺铁分别定义为铁蛋白
An adequate iron management is important in the treatment of anemia and in hemodialysis (HD) patients. Serum ferritin and transferrin saturation (TS) may be influenced by the presence of inflammation. Recently, the soluble transferrin receptor (s-TfR) has been advocated as a parameter of iron status in HD patients. The aim of the present study was to assess firstly the relation between serum ferritin, TS, and s-TfR in HD patients and to predict their agreement (assessed by kappa) in the diagnosis of iron deficiency, and, secondly, to assess the influence of inflammation on the relation between the parameters of iron state. Iron deficiency by either marker was respectively defined as ferritin