Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer
Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer
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DOI：
10.1007/s12105-007-0032-3
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发表时间：
2008-03-01
影响因子：
2.1
通讯作者：
Greer, Robert O.
中科院分区：
文献类型：
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作者：
Barrera, Jose E.;Shroyer, Kenneth R.;Greer, Robert O.
目的 目前的研究检查了雌激素受体 (ER)、孕激素受体 (PR) 和 p53 表达在腺样囊性癌 (ACC) 中的作用，以确定这些产物的简单表达或可能的过度表达是否可能影响这种癌症的发展和自然病程。研究设计 利用 47 份 ACC 标本的免疫组织化学评估来回顾性评估 ER 和 PR 状态以及 p53 过度表达。方法 对 47 份 ACC 标本和 47 份正常唾液腺组织样本的福尔马林固定石蜡包埋组织进行组织化学评估，以确定 ER、PR 和 p53 的存在。使用 0 至 + 3 等级对免疫反应性进行评分，其中染色为 (0) 阴性、(+ 1) 斑点、(+ 2) 弱阳性或 (+ 3) 强阳性。结果 47个肿瘤中有8个表达ER，47个肿瘤中有4个表达PR。 p53 畸变在 47 个肿瘤中的 26 个中得到证实。肿瘤表现出不同程度的免疫阳性，范围从0到+3。结论 这些研究表明 p53 畸变可能与 ACC 肿瘤进展有关，并且 ER 和 PR 可能在 ACC 发展中发挥作用。
Objectives The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer. Study Design ER and PR status and p53 overexpression were retrospectively evaluated utilizing immunohistochemical evaluation of 47 ACC specimens. Methods Formalin-fixed paraffin- embedded tissues from 47 ACC specimens and 47 samples of normal salivary gland tissue were evaluated histochemically for the presence of ER, PR and p53. Immunoreactivity was scored using a 0 to + 3 scale in which staining was either (0) negative, (+ 1) spotty, (+ 2) weakly positive, or (+ 3) strongly positive. Results ER was expressed in 8 of 47 tumors while PR was expressed in 4 of 47 tumors. p53 aberrations were demonstrated in 26 of 47 tumors. Tumors showed varying degrees of immunopositivity ranging from 0 to +3. Conclusions These studies suggest that p53 aberrations may be involved in ACC tumor progression and that ER and PR may play a role in ACC development.