Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients
Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients
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DOI：
10.1093/intimm/dxh387
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发表时间：
2006-03-01
影响因子：
4.4
通讯作者：
Postan, M
中科院分区：
文献类型：
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作者：
Albareda, MC;Laucella, SA;Postan, M
我们对记忆 CD8(+) T 细胞区室的成熟和迁移特性进行了横断面分析，该分析与远离流行地区超过 20 年的慢性克氏锥虫感染个体的心脏病严重程度相关。与患有更严重心脏病的受试者相比，没有或轻度心脏受累的受试者更有可能产生克氏锥虫特异性记忆IFN-γ反应，并且在反应个体中，克氏锥虫特异性CD8(+) T细胞群在早期分化(CD27(+)CD28(+))细胞中富集。相反，随着疾病的加重，CD27(+)CD28(+)CD8(+) T细胞在总记忆CD8(+) T细胞群中的频率降低，而完全分化的记忆(CD27(-)CD28(-)) CD8(+) T细胞的比例增加。 CCR7表达分析显示，与未感染的对照组相比，患有轻度心脏病的受试者中总效应/记忆CD8(+) T细胞(CD45RA(-)CCR7(-))显着增加。总而言之，这些结果与 CD8+ T 细胞群逐渐克隆衰竭的假设相一致，这可能是持久性寄生虫持续抗原刺激的结果。
We present a cross-sectional analysis of the maturation and migratory properties of the memory CD8(+) T cell compartment, in relation to the severity of heart disease in individuals with chronic Trypanosoma cruzi infection removed from endemic areas for longer than 20 years. Subjects with none or mild heart involvement were more likely to mount T. cruzi-specific memory IFN-gamma responses than subjects with more advanced cardiac disease, and the T. cruzi-specific CD8(+) T cell population was enriched in early-differentiated (CD27(+)CD28(+)) cells in responding individuals. In contrast, the frequency of CD27(+)CD28(+)CD8(+) T cells in the total memory CD8(+) T cell population decreases, as disease becomes more severe, while the proportion of fully differentiated memory (CD27(-)CD28(-)) CD8(+) T cells increases. The analysis of CCR7 expression revealed a significant increase in total effector/memory CD8(+) T cells (CD45RA(-)CCR7(-)) in subjects with mild heart disease as compared with uninfected controls. Altogether, these results are consistent with the hypothesis of a gradual clonal exhaustion in the CD8(+) T cell population, perhaps as a result of continuous antigenic stimulation by persistent parasites.