SYMPTOMS AT PRESENTATION FOR TREATMENT IN PATIENTS WITH LUNG-CANCER - IMPLICATIONS FOR THE EVALUATION OF PALLIATIVE TREATMENT
SYMPTOMS AT PRESENTATION FOR TREATMENT IN PATIENTS WITH LUNG-CANCER - IMPLICATIONS FOR THE EVALUATION OF PALLIATIVE TREATMENT
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DOI：
10.1038/bjc.1995.124
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发表时间：
1995-03-01
影响因子：
8.8
通讯作者：
STEPHENS, RJ
中科院分区：
文献类型：
--
作者：
HOPWOOD, P;STEPHENS, RJ
在鹿特丹症状检查表上，有650多名患者参加了两个MRC肺癌工作组多中心随机试验，其中包括一般症状（疲倦、食欲不振）和心理困扰（担忧、焦虑），以及与疾病相关的胸部症状（咳嗽、呼吸急促）。虽然症状的数量和严重程度随着运动状态的恶化而增加，但发现小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC）患者以及不同等级运动状态的最常见症状实际上是相同的。女性非小细胞肺癌患者报告的心理症状多于男性，但这种差异在SCLC患者中不太明显。因此，为了充分评估姑息治疗对肺癌患者的益处，除了传统上公认的胸部症状外，还必须考虑到所有症状。
The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addition to disease-related chest symptoms (cough, shortness of breath). Although the number and severity of symptoms increased with worsening performance status, the commonest symptoms were found to be virtually the same for patients with small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC), and for different grades of performance status. Women with NSCLC reported more psychological symptoms than males, but this difference was much less evident in patients with SCLC. Thus, in order to assess fully the benefit of palliative treatments in patients with lung cancer, account must be taken of all symptoms at presentation, in addition to the traditionally recognised chest symptoms.