ESCRT-dependent control of membrane remodelling during cell division.
ESCRT-dependent control of membrane remodelling during cell division.
复制标题
DOI：
10.1016/j.semcdb.2017.08.035
复制
发表时间：
2018-03
影响因子：
7.3
通讯作者：
Carlton JG
中科院分区：
文献类型：
--
作者：
Stoten CL;Carlton JG
运输所需的内体分选复合物 (ESCRT) 蛋白形成了进化上保守的膜重塑机制。最初因其在酵母液泡分选过程中的货物分选和内体膜重塑中的作用而被识别，现在大量的工作表明该机器的一个子复合体（ESCRT-III）是一种可移植的膜裂变机器，可以被分派到不同的细胞位置以实现拓扑上独特的膜分离。令人惊讶的是，细胞分裂期间发生了一些 ESCRT-III 调节的过程，此时细胞对其膜进行剧烈且协调的重塑，以允许分裂的物理过程发生。 ESCRT 机制在开放有丝分裂期间和胞质分裂的脱离阶段（子细胞在分裂的最后行为中彼此分离）的核膜再生中发挥作用。 ESCRT 机制在细胞分裂中的作用可以追溯到古细菌时期，这表明这些蛋白质的祖先作用是作为一种膜重塑机制，促进分裂，并在整个进化过程中被选择执行各种其他细胞生物学功能。在这里，我们将探讨 ESCRT 机制在细胞分裂中的功能和调节。
The Endosomal Sorting Complex Required for Transport (ESCRT) proteins form an evolutionarily conserved membrane remodelling machinery. Identified originally for their role in cargo sorting and remodelling of endosomal membranes during yeast vacuolar sorting, an extensive body of work now implicates a sub-complex of this machinery (ESCRT-III), as a transplantable membrane fission machinery that is dispatched to various cellular locations to achieve a topologically unique membrane separation. Surprisingly, several ESCRT-III-regulated processes occur during cell division, when cells undergo a dramatic and co-ordinated remodelling of their membranes to allow the physical processes of division to occur. The ESCRT machinery functions in regeneration of the nuclear envelope during open mitosis and in the abscission phase of cytokinesis, where daughter cells are separated from each other in the last act of division. Roles for the ESCRT machinery in cell division are conserved as far back as Archaea, suggesting that the ancestral role of these proteins was as a membrane remodelling machinery that facilitated division and that was co-opted throughout evolution to perform a variety of other cell biological functions. Here, we will explore the function and regulation of the ESCRT machinery in cell division.
登录
查看更多内容
影响因子：
21.3
作者：
Amaral, Nuno;Vendrell, Alexandre;Mendoza, Manuel
通讯作者：
Mendoza, Manuel
影响因子：
3.3
作者：
Bauer, Iva;Brune, Thomas;Koelling, Ralf
通讯作者：
Koelling, Ralf
影响因子：
5.7
作者：
Boura, Evzen;Rozycki, Bartosz;Chung, Hoi Sung;Herrick, Dawn Z.;Canagarajah, Bertram;Cafiso, David S.;Eaton, William A.;Hummer, Gerhard;Hurley, James H.
通讯作者：
Hurley, James H.
影响因子：
3.3
作者：
Aoh, Quyen L.;Castle, Anna M.;Castle, J. David
通讯作者：
Castle, J. David
影响因子：
4.8
作者：
Bowers, K;Piper, SC;Luzio, JP
通讯作者：
Luzio, JP