Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma.
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma.
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DOI：
10.1016/j.ejca.2016.12.035
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Ferris RL
中科院分区：
文献类型：
--
作者：
Moy JD;Moskovitz JM;Ferris RL
Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with high morbidity and mortality. Despite advances in cytotoxic therapies and surgical techniques, overall survival (OS) has not improved over the past few decades. This emphasises the need for intense investigation into novel therapies with good tumour control and minimal toxicity. Cancer immunotherapy has led this endeavour, attempting to improve tumour recognition and expand immune responses against tumour cells. While various forms of HNSCC immunotherapy are in preclinical trials, the most promising direction thus far has been with monoclonal antibodies (mAbs), targeting growth factor and immune checkpoint receptors. Preclinical and early phase trials have shown unprecedented efficacy with minimal adverse effects. This article will review biological mechanisms of immune escape and implications for immunotherapy in HNSCC.
