Attitudes of IVF/ICSI-twin mothers towards twins and single embryo transfer.
Attitudes of IVF/ICSI-twin mothers towards twins and single embryo transfer.
复制标题
IVF/ICSI 双胞胎母亲对双胞胎和单胚胎移植的态度。
作者：
A. Pinborg;A. Loft;L. Schmidt;A. Andersen
背景
我们的目的是研究有 3 至 4 岁孩子的 IVF/ICSI 双胞胎母亲对双胞胎和单胚胎移植 (SET) 的态度。
方法
通过问卷调查的方式进行了一项全国调查（n = 1769）。研究人群包括 IVF/ICSI 双胞胎母亲 (n = 266)，以及 IVF/ICSI 单胎母亲 (n = 764) 和非 IVF/ICSI 双胞胎母亲 (n = 739) 两个对照组，均于 1997 年在丹麦分娩。总体缓解率为 81%。
结果
与 IVF/ICSI 单胎母亲 (62.3%) 和非 IVF 双胞胎母亲 (60.0%) 相比，更多 IVF/ICSI 双胞胎母亲 (84.7%) 更喜欢双胞胎作为第一个孩子。与非 IVF/ICSI 双胞胎母亲相比，IVF/ICSI 双胞胎母亲对双胞胎的渴望明显更高（OR = 4.4，95% CI 2.8-6.9）。尽管 IVF/ICSI 双胎母亲 (23.4%) 和 IVF/ICSI 单胎母亲 (17.3%) 同意 SET 的比例相对较少，但出生体重极低 (VLBW) (<1500 g) 的孩子预示着 SET 的接受度很高（OR = 2.9，95% CI 1.2-6.9）。
结论
我们的研究表明，与非 IVF/ICSI 双胞胎母亲相比，IVF/ICSI 双胞胎母亲对双胞胎的渴望更大。尽管只有四分之一的 IVF/ICSI 母亲同意 SET，但生下患有 VLBW 的孩子并因此导致高发病率预示着 SET 的高度接受度。选择性 SET 的实施需要对不孕夫妇进行广泛的咨询，并且包括严格的选择标准在内的立法也可用于促进这一过程。
BACKGROUND
Our aim was to study attitudes towards twins and single embryo transfer (SET) among IVF/ICSI-twin mothers with 3 to 4-year old children.
METHODS
A national survey was conducted by questionnaire (n = 1769). The study population consisted of IVF/ICSI-twin mothers (n = 266), and the two control groups of IVF/ICSI-singleton mothers (n = 764) and non-IVF/ICSI-twin mothers (n = 739), all giving birth in Denmark in 1997. The overall response rate was 81%.
RESULTS
More IVF/ICSI-twin mothers (84.7%) preferred twins as their first child compared with IVF/ICSI-singleton mothers (62.3%) and non-IVF twin mothers (60.0%). The IVF/ICSI-twin mothers had a significantly higher wish for twins (OR = 4.4, 95% CI 2.8-6.9) compared with the non-IVF/ICSI-twin mothers. Though relatively few IVF/ICSI-twin mothers (23.4%) and IVF/ICSI-singleton mothers (17.3%) agreed to SET, delivery of a child with very low birth weight (VLBW) (<1500 g) was predictive of high acceptance of SET (OR = 2.9, 95% CI 1.2-6.9).
CONCLUSION
Our study suggests that IVF/ICSI-twin mothers have a greater wish for twins compared with non-IVF/ICSI-twin mothers. Despite the fact that only a quarter of IVF/ICSI mothers agreed to SET, delivery of a child with VLBW and hence high morbidity was predictive of high acceptance of SET. The implementation of elective SET requires extensive counselling of the infertile couples and legislation including strict selection criteria may also be used to facilitate this process.