HTO ORAL-ADMINISTRATION IN MICE .1. THRESHOLD DOSE-RATE FOR HEMATOPOIETIC DEATH
HTO ORAL-ADMINISTRATION IN MICE .1. THRESHOLD DOSE-RATE FOR HEMATOPOIETIC DEATH
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DOI：
10.1080/09553009014552681
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发表时间：
1990-03-01
影响因子：
2.6
通讯作者：
NOMURA, T
中科院分区：
文献类型：
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作者：
YAMAMOTO, O;YOKORO, K;NOMURA, T
在封闭动物室中连续口服不同浓度的氚化水（C57BL/6N和C3H/He）F1雌性小鼠。采用自动燃样系统和液体闪烁计数器，在氚化水启动后，定期测量各器官组织中的氚放射性。7天后，比放射性达到平稳状态。这些数据可以用来估计吸收器官的剂量。在1倍的范围内。10点11分到5点92分。饮用水中氚水浓度为1011 Bq/dm3，开始给药后死亡时间约为2周，为典型的造血死亡时间。在对数-对数尺度上观察到，死亡时间与饮用水中氚化水浓度呈线性关系，在1.cntdot.85。1010 Bq/dm3和1.cntdot.48倍。1011 Bq / dm3。浓度低于0.025倍。109 Bq/dm3，小鼠不再死于造血功能衰竭。因此，我们得出结论，造血死亡应该有一个阈值剂量率。
Tritiated water in various concentrations was orally administered continuously to (C57BL/6N and C3H/He)F1 female mice in a closed animal chamber. Tritium radioactivity in various organ tissues was measured periodically after initiating tritiated water intake using an automatic sample combustion system and a liquid scintillation counter. After 7 days the specific radioactivity reached a plateau. These data allowed absorbed organ doses to be estimated. Within a range of 1.cntdot.48 .times. 1011 to 5.cntdot.92 .times. 1011 Bq/dm3 as the concentration of tritiated water in drinking water, the time, of death after initiating the administration was about 2 weeks, a typical time for haematopoietic death. A linear relationship of times of death with tritiated water concentrations in drinking water was observed, on a log-log scale, between 1.cntdot.85 .times. 1010 Bq/dm3 and 1.cntdot.48 .times. 1011 Bq/dm3. At concentrations lower than 9.cntdot.25 .times. 109 Bq/dm3, mice no longer died from haematopoietic failure. We conclude, therefore, that there should be a threshold dose rate for haematopoietic death.