Photoperiodic Programming of the SCN and Its Role in Photoperiodic Output.

Photoperiodic Programming of the SCN and Its Role in Photoperiodic Output.
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DOI:
10.1155/2018/8217345
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发表时间:
2018
期刊:
影响因子:
3.1
通讯作者:
McMahon DG
McMahon DG
中科院分区:
医学4区
文献类型:
--
作者:
Tackenberg MC;McMahon DG

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尽管生物体对日长变化的季节性反应是一个近一个世纪以来一直被科学报道的现象,但关于光周期是如何编码和影响神经生物学的重大问题仍然存在。在哺乳动物中,早期的工作确定了主生物钟-视交叉上核(SCN)--作为光周期信息的暂定编码者。在这里,我们提供了关于SCN作为光周期反应的协调者的研究概况,伴随着这种协调的细胞间耦合变化,以及SCN在可能控制光周期输入和输出的大脑网络中的作用。最后,我们在通过这项研究实现了对人类健康的切实好处的背景下,讨论了光周期研究的重要性以及仍然存在的挑战。
Though the seasonal response of organisms to changing day lengths is a phenomenon that has been scientifically reported for nearly a century, significant questions remain about how photoperiod is encoded and effected neurobiologically. In mammals, early work identified the master circadian clock, the suprachiasmatic nuclei (SCN), as a tentative encoder of photoperiodic information. Here, we provide an overview of research on the SCN as a coordinator of photoperiodic responses, the intercellular coupling changes that accompany that coordination, as well as the SCN's role in a putative brain network controlling photoperiodic input and output. Lastly, we discuss the importance of photoperiodic research in the context of tangible benefits to human health that have been realized through this research as well as challenges that remain.
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