Respiratory sinus arrhythmia reactivity to a sad film predicts depression symptom improvement and symptomatic trajectory.
Respiratory sinus arrhythmia reactivity to a sad film predicts depression symptom improvement and symptomatic trajectory.
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DOI：
10.1016/j.ijpsycho.2015.12.002
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Rottenberg J
中科院分区：
文献类型：
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作者：
Panaite V;Hindash AC;Bylsma LM;Small BJ;Salomon K;Rottenberg J
呼吸性窦性心律失常（RSA）反应性是心脏迷走神经张力的一个指标，与自我调节和抑郁症的严重程度和病程有关。虽然最初的数据支持这一命题，即在一个悲伤的电影RSA撤退是一个特定的预测抑郁症的过程中，这一发现的鲁棒性和特异性还不清楚。为了提供一个更强的测试，RSA反应三个情绪电影（快乐，悲伤，恐惧）和一个更强大的压力，一个语音任务，进行了检查，目前抑郁症患者（n = 37），他们的症状改善程度进行了评估超过30周。RSA对悲伤电影的强烈反应性唯一预测了30周内的整体症状改善。RSA反应悲伤和压力刺激预测的速度和维护症状的改善。目前的分析提供了迄今为止最有力的支持，即RSA对悲伤刺激（但不是压力）的退缩在预测整体症状改善方面具有特异性。相比之下，RSA对负面刺激（悲伤和压力）的反应可以预测抑郁过程的轨迹。患者对悲伤刺激的参与可能是治疗环境中需要注意的重要标志。
Respiratory sinus arrhythmia (RSA) reactivity, an index of cardiac vagal tone, has been linked to self-regulation and the severity and course of depression. Although initial data supports the proposition that RSA withdrawal during a sad film is a specific predictor of depression course, the robustness and specificity of this finding are unclear. To provide a stronger test, RSA reactivity to three emotion films (happy, sad, fear) and to a more robust stressor, a speech task, were examined in currently depressed individuals (n = 37), who were assessed for their degree of symptomatic improvement over 30 weeks. Robust RSA reactivity to the sad film uniquely predicted overall symptom improvement over 30 weeks. RSA reactivity to both sad and stressful stimuli predicted the speed and maintenance of symptomatic improvement. The current analyses provide the most robust support to date that RSA withdrawal to sad stimuli (but not stressful) has specificity in predicting the overall symptomatic improvement. In contrast, RSA reactivity to negative stimuli (both sad and stressful) predicted the trajectory of depression course. Patients’ engagement with sad stimuli may be an important sign to attend to in therapeutic settings.