Terahertz pulse imaging of ex vivo basal cell carcinoma
Terahertz pulse imaging of ex vivo basal cell carcinoma
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DOI：
10.1046/j.1523-1747.2003.12013.x
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发表时间：
2003-01-01
影响因子：
6.5
通讯作者：
Pepper, M
中科院分区：
文献类型：
--
作者：
Woodward, RM;Wallace, VP;Pepper, M
太赫兹脉冲成像首次用于离体研究基底细胞癌，这是最常见的皮肤癌形式。这种非侵入性技术使用频率范围为0.1-2.7 THz的部分电磁频谱。共对21个样本进行了成像;该研究是盲法进行的，并将结果与组织学进行了比较。每个图像由来自同一患者的可能的病变组织和正常组织组成。与正常组织相比，患病组织显示出吸收增加，这归因于患病组织内间隙水的增加或具有其他官能团的水分子的振动模式的变化。其中17张图像显示正常组织和病变组织之间存在显著差异。经组织学证实为基底细胞癌。在其余4例中，3例未显示造影剂，并被确认为正常组织的盲对照;第4例疑似基底细胞癌，但未显示造影剂，组织学检查显示无肿瘤。将显示太赫兹吸收的太赫兹图像的横截面与组织学进行比较。太赫兹吸收增加的区域与肿瘤部位的位置一致。我们的系统在1太赫兹的分辨率为350妈妈横向和40妈妈轴向皮肤可达到。这些结果证明了太赫兹脉冲成像区分基底细胞癌和正常组织的能力，这种宏观技术在未来可能有助于计划手术。
Terahertz pulse imaging has been used for the first time to study basal cell carcinoma ex vivo , the most common form of skin cancer. This noninvasive technique uses part of the electromagnetic spectrum in the frequency range 0.1-2.7 THz. A total of 21 samples were imaged; the study was performed blind and results were compared to histology. Each image consisted of possible diseased tissue and normal tissue from the same patient. The diseased tissue showed an increase in absorption compared to normal tissue, which is attributed to either an increase in the interstitial water within the diseased tissue or a change in the vibrational modes of water molecules with other functional groups. Seventeen of the images showed a significant difference between the normal and the diseased tissue. These were confirmed by histology to be basal cell carcinomas. Of the remaining four cases, three showed no contrast and were confirmed as blind controls of normal tissue; the fourth case was a suspected basal cell carcinoma but showed no contrast, and histology showed no tumor. Cross-sections of the terahertz images, showing the terahertz absorption, were compared to histology. Regions of increased terahertz absorption agreed well with the location of the tumor sites. Resolutions at 1 THz of 350 mum laterally and 40 mum axially in skin were attainable with our system. These results demonstrate the ability of terahertz pulse imaging to distinguish basal cell carcinoma from normal tissue, and this macroscopic technique may, in the future, help plan surgery.