Decreased E-cadherin but not β-catenin expression is associated with vascular invasion and decreased survival in head and neck squamous carcinomas
Decreased E-cadherin but not β-catenin expression is associated with vascular invasion and decreased survival in head and neck squamous carcinomas
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DOI：
10.1016/j.otohns.2005.08.026
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发表时间：
2006-01-01
影响因子：
3.4
通讯作者：
Robinson, RA
中科院分区：
文献类型：
--
作者：
Kurtz, KA;Hoffman, HT;Robinson, RA
目的：我们希望相关的表达E-钙粘蛋白和β-连环蛋白在鳞状细胞癌的头部和颈部的结果和其他临床病理variable.Study设计和设置：这项回顾性研究进行了三级护理设置。45例头颈部鳞状细胞癌患者的肿瘤主要通过切除术治疗，用E-cadherin和β-catenin抗体进行免疫组化评价。32例发生于口腔，9例发生于喉，4例发生于下咽。患者预后和肿瘤部位、肿瘤分期、颈淋巴结状态、肿瘤分化、神经周围浸润和血管浸润等临床病理变量与E-cadherin和beta-catenin的免疫组化表达相关。E-cadherin在肿瘤中的低表达与总生存率的降低显著相关（P = 0.004）、无病生存期（P = 0.007）和血管浸润（P = 0.02），但与其他临床病理变量无关。β-连环蛋白表达与任何研究的临床病理变量无显著相关性。结论：E-cadherin表达降低而β-连环蛋白表达不降低与头颈部鳞状细胞癌患者生存率降低相关。检测E-缺失cadherin的表达可能有助于预测哪些头颈部鳞状细胞癌患者的预后会比那些肿瘤未分化的患者更差。失去了这个肿瘤抑制因子循证医学评级：C-4（C）2006年美国耳鼻咽喉头颈外科基金会学会。All rights reserved.
OBJECTIVE: We wished to correlate the expression of E-cadherin and beta-catenin in squamous carcinomas of the head and neck to outcome and other clinicopathologic variables.STUDY DESIGN AND SETTING: This retrospective study was carried out in a tertiary care setting. The tumors of 45 patients who had their head and neck squamous carcinoma primarily treated by resection were evaluated immunohistochemically with antibodies to E-cadherin and beta-catenin. Thirty-two tumors arose in the oral cavity, 9 tumors originated in the larynx, and 4 tumors began in the hypopharynx. Patient outcome and the clinicopathologic variables of tumor site, tumor stage, cervical lymph node status, tumor differentiation, perineural invasion, and vascular invasion were correlated to immunohistochemical expression of E-cadherin and beta-catenin.RESULTS: Low expression of E-cadherin in the tumors was significantly associated with decreased overall survival (P = 0.004), disease-free survival (P = 0.007), and vascular invasion (P = 0.02) but not with other clinicopathologic variables. beta-catenin expression was not significantly associated with any of the studied clinicopathologic variables.CONCLUSION: Decreased E-cadherin but not beta-catenin expression is associated with decreased survival in patients with head and neck squamous carcinomas.SIGNIFICANCE: Detection of loss of E-cadherin expression may help predict which patients with head and neck squamous cell carcinoma will experience a worse outcome compared to patients whose tumors have not lost this tumor suppressor. EBM rating: C-4 (C) 2006 American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc. All rights reserved.