MOUSE HEPATITIS-VIRUS TYPE-4 (JHM STRAIN)-INDUCED FATAL CENTRAL NERVOUS-SYSTEM DISEASE .1. GENETIC-CONTROL AND THE MURINE NEURON AS THE SUSCEPTIBLE SITE OF DISEASE
MOUSE HEPATITIS-VIRUS TYPE-4 (JHM STRAIN)-INDUCED FATAL CENTRAL NERVOUS-SYSTEM DISEASE .1. GENETIC-CONTROL AND THE MURINE NEURON AS THE SUSCEPTIBLE SITE OF DISEASE
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DOI：
10.1084/jem.153.4.832
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发表时间：
1981-01-01
影响因子：
15.3
通讯作者：
OLDSTONE, MBA
中科院分区：
文献类型：
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作者：
KNOBLER, RL;HASPEL, MV;OLDSTONE, MBA
小鼠肝炎病毒(JHM株)4型在许多品系的实验小鼠中引起急性脑炎并随后死亡。体内免疫组织化学研究和体外小鼠神经细胞分析表明，本次感染的靶细胞为神经元。对几个近交系小鼠及其神经细胞的检查表明，疾病的表达是由单个常染色体基因在神经细胞水平上控制的。敏感性是显性的，但不是H-2连锁的。SJL/J小鼠培养的神经细胞和巨噬细胞对这种感染具有抵抗力，但在适当的病毒接种后，无法产生大量的感染性病毒。显然，缺陷不在病毒细胞受体的水平上，因为这些细胞在一定程度上表达病毒抗原。
Mouse hepatitis virus (JHM strain) type 4 induces acute encephalitis followed by death in many strains of laboratory mice. Immunohistochemical study in vivo and analysis of mouse neuronal cells in vitro indicate that the target cell in this infection is the neuron. Examination of several inbred mouse strains and their neuronal cells shows that disease expression is controlled by a single autosomal gene acting at the level of the neuronal cell. Susceptibility is dominant but not H-2 linked. Cultured neuronal cells and macrophages from SJL/J mice, which are resistant to this infection, fail to make significant amounts of infectious virus after an appropriate viral inoculation. Apparently the defect is not at the level of the virus-cell receptor because these cells, in part, express viral antigens.