Response linearity of alert monkey non-eye movement vestibular nucleus neurons during sinusoidal yaw rotation.
Response linearity of alert monkey non-eye movement vestibular nucleus neurons during sinusoidal yaw rotation.
复制标题
正弦偏航旋转期间警觉猴非眼动前庭核神经元的响应线性。
DOI：
10.1152/jn.90914.2008
复制
发表时间：
2009
影响因子：
2.5
通讯作者：
Wei,Min
中科院分区：
文献类型：
--
作者：
Newlands,ShawnD;Lin,Nan;Wei,Min
前庭传入神经在一定的振幅和频率范围内显示线性反应，但中枢前庭神经元的可比数据缺乏。为了研究刺激频率和强度对非眼动中枢前庭神经元反应灵敏度和线性的影响，我们记录了清醒恒河猴前庭核在正弦偏航旋转过程中，频率在0.1和2 Hz之间，峰值速度在7.5和210°/s之间。在保持峰值速度恒定的情况下，神经元对频率的响应动力学与以前的研究一致。然而，随着峰值速度的变化，同时保持频率恒定，神经元表现出较低的敏感性，随着峰值速度的增加，即使在最低的峰值速度测试。随着峰值速度的增加，在部分反应期间沉默的神经元的比例增加。然而，这些神经元的灵敏度降低与更高的旋转峰值速度是不是由于增加沉默在抑制部分的周期。相反，当旋转的峰值速度增加时，神经元显示的峰值放电率并不与头部速度成比例地增加。这些数据表明，不像前庭传入，在这项研究中没有眼动敏感性检查的中央前庭神经元不遵循线性系统的原则，即使在低速度。
Vestibular afferents display linear responses over a range of amplitudes and frequencies, but comparable data for central vestibular neurons are lacking. To examine the effect of stimulus frequency and magnitude on the response sensitivity and linearity of non-eye movement central vestibular neurons, we recorded from the vestibular nuclei in awake rhesus macaques during sinusoidal yaw rotation at frequencies between 0.1 and 2 Hz and between 7.5 and 210°/s peak velocity. The dynamics of the neurons' responses across frequencies, while holding peak velocity constant, was consistent with previous studies. However, as the peak velocity was varied, while holding the frequency constant, neurons demonstrated lower sensitivities with increasing peak velocity, even at the lowest peak velocities tested. With increasing peak velocity, the proportion of neurons that silenced during a portion of the response increased. However, the decrease in sensitivity of these neurons with higher peak velocities of rotation was not due to increased silencing during the inhibitory portion of the cycle. Rather the neurons displayed peak firing rates that did not increase in proportion to head velocity as the peak velocity of rotation increased. These data suggest that, unlike vestibular afferents, the central vestibular neurons without eye movement sensitivity examined in this study do not follow linear systems principles even at low velocities.