The usefulness of DST in predicting response to antidepressants: a placebo-controlled study.
The usefulness of DST in predicting response to antidepressants: a placebo-controlled study.
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DST 在预测抗抑郁药反应方面的作用：一项安慰剂对照研究。
DOI：
10.1016/0165-0327(86)90055-8
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发表时间：
1986
影响因子：
6.6
通讯作者：
Cooper,TB
中科院分区：
文献类型：
--
作者：
Georgotas,A;Stokes,P;McCue,RE;Dubow,A;Welkowitz,J;Friedman,E;Fanelli,C;Chang,I;Cooper,TB
72 名 55 岁或以上患有重度抑郁症的门诊患者在安慰剂对照双盲条件下接受了去甲替林或苯乙肼治疗七周。在基线以及治疗第 3 周和第 7 周进行地塞米松抑制试验 (DST)，并检查其在预测和/或平行临床反应中的有用性。基线药敏试验结果与抗抑郁药治疗反应之间没有发现相关性。在 13 名基线 DST 异常在治疗期间恢复正常的患者中，6 名有反应，7 名无反应（P = 0.24）。然而，所有（七名）药敏试验在七周内持续异常的患者均未做出反应。作者得出的结论是，DST 尚未被证明具有作为老年人重度抑郁即将恢复的指标的实用价值，但其未能正常化可能具有不祥的预后意义。
Seventy-two out-patients, 55 years or older, suffering from major depression were treated with either nortriptyline or phenelzine for seven weeks under placebo-controlled double-blind conditions. The dexamethasone suppression test (DST) was administered at baseline and at weeks 3 and 7 of treatment, and its usefulness in predicting and/or paralleling clinical response was examined. No correlation was found between baseline DST results and treatment response with antidepressants. Of 13 patients whose abnormal baseline DSTs normalized during treatment, six were responders and seven were nonresponders (P= 0.24). However, all (seven) patients whose DSTs persisted to be abnormal throughout the seven weeks did not respond. The authors conclude that the DST has not been shown to have practical value as an indicator of impending recovery from major depression in the elderly, but its failure to normalize may have ominous prognostic significance.