REDUCED JOINT COUNTS IN CONTROLLED CLINICAL-TRIALS IN RHEUMATOID-ARTHRITIS
REDUCED JOINT COUNTS IN CONTROLLED CLINICAL-TRIALS IN RHEUMATOID-ARTHRITIS
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DOI：
10.1002/art.1780370406
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发表时间：
1994-04-01
影响因子：
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通讯作者：
PINCUS, T
中科院分区：
文献类型：
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作者：
FUCHS, HA;PINCUS, T
Objective.为了确定减少关节数量的定量评估是否提供了与传统的60个关节评估在检测参与类风湿关节炎（RA）临床试验的患者的变化中获得的信息等同的信息。对3项既往报告的临床试验中患者的定量关节评分变化进行了汇总，并与使用减少关节数量得出的定量评分变化进行了比较。计算影响大小（关节评分的平均变化/关节评分的标准差）并比较不同关节指数。使用减少的关节数量得出的关节评分的效应量与原始60关节评分的效应量相似。关节计数评分的降低揭示了涉及15例患者的临床试验的显著变化。降低的关节计数评分可用于评价临床试验的结果，而不会降低检测随时间变化的能力。减少关节数量的定量评估也可能有助于评估RA患者常规护理中对治疗的反应。
Objective. To determine if quantitative assessment of a reduced number of joints provides information equivalent to that obtained by the traditional 60-joint evaluation in detecting changes in patients participating in clinical trials of rheumatoid arthritis (RA).Methods. The changes in quantitative joint scores of patients from 3 previously reported clinical trials were compiled and compared with changes in quantitative scores derived using a reduced number of joints. Effect sizes were calculated (mean change in joint score/standard deviation of joint score) and compared for the different joint indices.Results. The effect sizes of the joint scores derived using a reduced number of joints were similar to those of the original 60-joint score. The reduced joint count scores revealed significant changes for clinical trials involving as few as 15 patients.Conclusion. Reduced joint count scores may be used to evaluate the results of clinical trials without decreasing the ability to detect change over time. Quantitative assessment of a reduced number of joints may also facilitate assessment of responses to treatment in the routine care of patients with RA.