A functional role for the ventrolateral prefrontal cortex in non-spatial auditory cognition
A functional role for the ventrolateral prefrontal cortex in non-spatial auditory cognition
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DOI：
10.1073/pnas.0907248106
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发表时间：
2009-11-24
影响因子：
11.1
通讯作者：
Nitecki, R.
中科院分区：
文献类型：
--
作者：
Cohen, Y. E.;Russ, B. E.;Nitecki, R.
空间和非空间的感觉信息被假设为在平行的途径进行评估。在这项研究中，我们测试的空间和非空间敏感性的听觉神经元在腹外侧前额叶皮层（vPFC），在非空间通路的皮质区。当非人类灵长类动物报告听觉刺激的空间或非空间特征的变化时，测试活动。我们发现，vPFC神经元在非空间听觉任务中被可靠地调制，但在空间听觉任务中不被调制。在非空间任务过程中的调制程度与猴子的行为表现呈正相关。这些结果与vPFC是参与非空间听觉处理的电路的一部分以及vPFC在非空间听觉认知中起功能性作用的假设是一致的。
Spatial and non-spatial sensory information is hypothesized to be evaluated in parallel pathways. In this study, we tested the spatial and non-spatial sensitivity of auditory neurons in the ventrolateral prefrontal cortex (vPFC), a cortical area in the non-spatial pathway. Activity was tested while non-human primates reported changes in an auditory stimulus' spatial or non-spatial features. We found that vPFC neurons were reliably modulated during a non-spatial auditory task but were not modulated during a spatial auditory task. The degree of modulation during the non-spatial task correlated positively with the monkeys' behavioral performance. These results are consistent with the hypotheses that the vPFC is part of a circuit involved in non-spatial auditory processing and that the vPFC plays a functional role in non-spatial auditory cognition.