A RNS-LIKE REGULATORY GENE FOR COLONIZATION FACTOR ANTIGEN-I (CFA/I) THAT CONTROLS EXPRESSION OF CFA/I PILIN
A RNS-LIKE REGULATORY GENE FOR COLONIZATION FACTOR ANTIGEN-I (CFA/I) THAT CONTROLS EXPRESSION OF CFA/I PILIN
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DOI：
10.1128/iai.58.4.874-878.1990
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发表时间：
1990-04-01
影响因子：
3.1
通讯作者：
SCOTT, JR
中科院分区：
文献类型：
--
作者：
CARON, J;SCOTT, JR
Colonization factor antigens (CFA) are needed for adherence of human enterotoxigenic Escherichia coli (ETEC) strains to their hosts. The CFA/II antigens, CS1 and CS2, which are found in some ETEC strains, require the plasmid-encoded gene rns for expression (J. Caron, L. M. Coffield, and J. R. Scott, Proc. Natl. Acad. Sci. USA 86:963-967, 1989). Other ETEC strains express CFA/I, whose synthesis and assembly require genes on two unlinked regions (regions 1 and 2) of a plasmid (G. A. Willshaw, H. R. Smith, and B. Rowe, FEMS Microbiol. Lett. 16:101-106, 1983). We report that CFA/I region 2 DNA can substitute for rns to cause expression of CS1 and CS2. The cfaR gene in region 2 is defined by a mutation abolishing both expression of CFA/I and complementation of a rns mutant for expression of CS1 or CS2. In a strain containing only region 1, complementation for expression of CFA/I by a plasmid containing rns+ is inefficient but is adequate to cause hemagglutination by the CFA/I adhesin.
