Cross-Sectional Study to Determine the Prevalence of Hepatitis B and C Virus Infection in High Risk Groups in the Northeast Region of Brazil
Cross-Sectional Study to Determine the Prevalence of Hepatitis B and C Virus Infection in High Risk Groups in the Northeast Region of Brazil
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DOI：
10.3390/ijerph14070793
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发表时间：
2017-07-01
影响因子：
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通讯作者：
Villar, Livia Melo
中科院分区：
文献类型：
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作者：
Barbosa, Jakeline Ribeiro;Bezerra, Cristianne Sousa;Villar, Livia Melo
背景：HBV（B型肝炎病毒）和HCV（丙型肝炎病毒）感染在易感人群中比一般人群更普遍。本研究的目的是调查HIV阳性患者（GI）、慢性肾功能衰竭（CRF）患者（GII）和凝血功能障碍患者（GIII）中HBV和HCV感染的患病率。方法：2014年6月至2015年3月进行了一项横断面研究。采用酶联免疫吸附试验（ELISA）检测血清样本中的B和C型肝炎标志物。使用Epi Info（TM）7进行社会人口统计学、流行病学、临床和实验室数据以及伴随的统计分析。结果：共招募了348名个体，即，154名艾滋病毒阳性患者、143名慢性肾功能衰竭患者和51名凝血功能障碍患者。其中，超过66%为男性，GI和GIII的主要年龄组分别为26-35岁和56-65岁。大多数患者的受教育年限超过8年（GI为66.2%，GIII为60.6%，GII为46.1%），超过48%的患者的家庭收入在100-400美元之间。GI、GII和GIII的HBsAg标志物检出率分别为3.9%、7%和3.9%，总抗-HBc检出率分别为28.6%、55.9%和31.4%，抗-HCV检出率分别为1.3%、12.6%和47%。然而，抗-HBs的患病率在所有组中均大于70%。结论：这项研究表明，与一般人群相比，特定人群中HBV和HCV的患病率较高。年龄、收入、性伴侣数量、性传播疾病负担、输血史或1994年以前的血液制品和输血等因素与这些感染的较高患病率有关。
Background: HBV (Hepatitis B Virus) and HCV (Hepatitis C Virus) infections are more prevalent in vulnerable populations than the general population. The objective of this study was to investigate the prevalence of HBV and HCV infection in HIV-positive patients (GI), chronic renal failure (CRF) patients (GII) and coagulation disorder individuals (GIII). Methods: A cross-sectional study was conducted from June 2014 to March 2015. Serum samples were tested for markers of hepatitis B and C by enzyme-linked immunosorbent assay (ELISA). Sociodemographic, epidemiological, clinical and laboratory data and accompanying statistical analyses were performed using Epi Info (TM) 7. Results: A total of 348 individuals were recruited, i.e., 154 HIV-positive, 143 CRF and 51 coagulopathy patients. Among them, more than 66% were men, and the predominant age group was 26-35 years in GI and 56-65 years in GIII. Most patients had more than 8 years of education (66.2% in GI, 60.6% in GIII and 46.1% in GII), with a family income between 100-400 dollars in more than 48% of patients. The prevalence of the HBsAg marker was 3.9%, 7% and 3.9%, total anti-HBc was 28.6%, 55.9% and 31.4%, and anti-HCV was 1.3%, 12.6% and 47% for GI, GII and GIII, respectively. However, the prevalence of anti-HBs was greater than 70% in all groups. Conclusions: This study shows a high prevalence of HBV and HCV among specific groups compared to the general population. Factors such as age, income, number of sexual partners, sexually transmitted disease burden, blood transfusion history or blood products and blood transfusions before 1994 were associated with a higher prevalence for these infections.