The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyperreflexia associated with inflammation of the rat urinary bladder
The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyperreflexia associated with inflammation of the rat urinary bladder
复制标题
DOI：
10.1016/s0304-3940(98)00621-1
复制
发表时间：
1998-09-04
影响因子：
2.5
通讯作者：
Rice, ASC
中科院分区：
文献类型：
--
作者：
Jaggar, SI;Sellaturay, S;Rice, ASC
大麻素酰胺，在CB 1大麻素受体的内源性配体和棕榈酰乙醇酰胺（一个假定的内源性配体在CB 2受体）都已被证明具有抗痛觉过敏的身体和内脏炎症模型中的特性。在松节油发炎的大鼠膀胱的炎症相关的内脏内脏反射亢进（WH）的逆转时，观察到大麻素的诱导炎症后135分钟。因此，在本研究中，我们确定了这两种N-酰基乙醇酰胺在相同模型中使用预防性给药方案预防VVH的功效。棕榈酰乙醇胺不能预防VVH（剂量范围为10-30 mg/kg，i.a.），但花生四烯酸酰胺以剂量相关的方式减弱反应，阈值为25 mg/kg（i.a.）。这些发现为CB 1受体激动剂的急性抗伤害感受和抗痛觉过敏作用提供了进一步的支持，而CB 2激动剂的作用只有在炎症作用确立后才变得重要。(C)1998由Elsevier Science爱尔兰有限公司出版。保留所有权利。
Anandamide, an endogenous ligand at the CB1 cannabinoid receptor and palmitoylethanolamide (a putative endogenous ligand at the CB2 receptor) have both been shown to possess anti-hyperalgesic properties in models of somatic and visceral inflammation. In the turpentine-inflamed rat urinary bladder a reversal of the inflammation-associated viscero-visceral hyperreflexia (WH) was observed when the cannabinoids were administered 135 min after the induction of inflammation. Therefore, in this study we determined the efficacy of these two N-acylethanolamides in the prevention of VVH in the same model, using a prophylactic dosing regimen. Palmitoylethanolamide did not prevent the VVH (in the dose range 10-30 mg/kg, i.a), but anandamide attenuated the response in a dose related manner, with a threshold of 25 mg/kg (i.a). These findings provide further support for an acute anti-nociceptive and anti-hyperalgesic role for CB1 receptor agonists, with CB2 agonist effects only becoming important once the effects of inflammation are established. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.