Clinical and pathologic risk factors for atherosclerosis in cirrhosis: A comparison between NASH-related cirrhosis and cirrhosis due to other aetiologies
Clinical and pathologic risk factors for atherosclerosis in cirrhosis: A comparison between NASH-related cirrhosis and cirrhosis due to other aetiologies
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DOI：
10.1016/j.jhep.2008.05.024
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发表时间：
2008-10-01
影响因子：
25.7
通讯作者：
Bass, Nathan M.
中科院分区：
文献类型：
--
作者：
Kadayifci, Abdurrahman;Tan, Vivian;Bass, Nathan M.
背景/目的：NASH相关肝硬化患者动脉粥样硬化危险因素的确切患病率尚不清楚。本研究的目的是：（1）比较因NASH相关性肝硬化接受肝移植的受试者与其他病因肝硬化受试者之间动脉粥样硬化主要危险因素的患病率，（2）比较各组之间肝门动脉外植体内动脉粥样硬化的病理变化。对60例NASH相关肝硬化和60例其他病因肝硬化患者进行了回顾性分析。分析和比较与动脉粥样硬化相关的人口统计学和临床特征。结果：NASH相关肝硬化组所有冠心病（CAD）危险因素和代谢综合征的患病率显著高于其他病因肝硬化组。NASH相关肝硬化组中诊断为CAD的患者比例也显著较高（21.6% vs. 5%，p = 0.005）。肝门动脉的病理检查显示可能的动脉粥样硬化的变化，只有4例（3 NASH相关肝硬化; 1 HCV）。结论：动脉粥样硬化的主要危险因素是显着更普遍的NASH相关肝硬化的受试者比其他活动性肝硬化的受试者，并预测CAD的患病率增加。这项研究表明，NASH相关的肝硬化对动脉粥样硬化没有保护作用。(C)2008年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: The precise prevalence of risk factors for atherosclerosis in NASH-related cirrhosis is unknown. The aims of this study were: (1) to compare the prevalence of major risk factors for atherosclerosis between subjects who underwent liver transplantation for NASH-related cirrhosis and those with cirrhosis of other aetiologies and (2) to compare pathologic changes of atherosclerosis within the explants hepatic hilar arteries between the groups.Methods: Sixty subjects with NASH-related cirrhosis and 60 subjects with cirrhosis of other aetiologies were reviewed retrospectively. Demographic and clinical characteristics related to atherosclerosis were analyzed and compared. The hepatic hilar arteries of the explanted livers were examined for pathologic changes.Results: The prevalence of all coronary artery disease (CAD) risk factors and the metabolic syndrome was significantly higher in NASH-related cirrhosis group compared to cirrhosis of other aetiologies. The proportion of patients with a diagnosis of CAD was also significantly higher in the NASH-related cirrhosis group (21.6% vs. 5%, p = 0.005). Pathological examination of hilar arteries showed possible atherosclerotic changes in only 4 cases (3 NASH-related cirrhosis; 1 HCV).Conclusions: Major risk factors for atherosclerosis are significantly more prevalent in subjects with NASH-related cirrhosis than in subjects with cirrhosis of other actiologies and are predictive of an increased prevalence of CAD. This study suggests that NASH-related cirrhosis is not protective against atherosclerosis. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.