Aquaporins in Urinary Extracellular Vesicles (Exosomes).
Aquaporins in Urinary Extracellular Vesicles (Exosomes).
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DOI：
10.3390/ijms17060957
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发表时间：
2016-06-17
影响因子：
5.6
通讯作者：
Ikeda M
中科院分区：
文献类型：
--
作者：
Oshikawa S;Sonoda H;Ikeda M
自从 Knepper 团队于 2004 年成功表征尿液细胞外囊泡 (uEV) 以来，这些囊泡一直是全球基础研究和转化研究的焦点，旨在开发肾脏疾病的新型生物标志物和治疗方法。随着这些研究的开展，越来越多的证据表明，uEV 中的水通道蛋白 (AQP)、水通道蛋白有可能具有诊断用途。在这篇综述中，我们重点介绍了 uEV 中 AQP 从发现到临床应用的最新知识。
Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper’s group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs have the potential to be diagnostically useful. In this review, we highlight current knowledge of AQPs in uEVs from their discovery to clinical application.