Collagen remodeling during decidualization in the mouse
Collagen remodeling during decidualization in the mouse
复制标题
小鼠蜕膜化过程中的胶原重塑
DOI：
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发表时间：
2004
影响因子：
3.6
通讯作者：
Dr. P. A. Abrahamsohn
中科院分区：
文献类型：
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作者：
T. Zorn;E. Bevilacqua;Dr. P. A. Abrahamsohn
本研究对未孕和孕2 ~ 11天小鼠子宫内膜胶原纤维的形态和分布进行了超微结构研究。在妊娠第2天的成纤维细胞的细胞质中观察到含胶原的结构。用硝酸镧处理组织，证实这些结构是胞浆内的。它们与溶酶体样小体的关系提示细胞内胶原消化的发生，可能与蜕膜化前子宫内膜间质的重塑有关。在妊娠第4天，细胞间隙中存在非常少的胶原纤维。从妊娠第6天起，蜕膜细胞间可见“粗”的胶原纤维。这些原纤维的直径测得高达300 nm，而处女小鼠子宫内膜中存在的原纤维测得为40-68 nm。
SummaryAn ultrastructural study of the features and distribution of collagen fibrils was performed in the endometrium of virgin and pregnant (2nd to 11th day) mice. Collagen-containing structures were observed in the cytoplasm of fibroblasts on the 2nd day of pregnancy. Treatment of tissues with lanthanum nitrate established that these structures were intracytoplasmic. Their association with lysosome-like bodies suggested the occurrence of intracellular digestion of collagen, probably connected with remodeling of the endometrial stroma prior to decidualization. On the 4th day of pregnancy, very few collagen fibrils were present in the intercellular space. From the 6th day of pregnancy onwards, “thick” collagen fibrils were observed between decidual cells. The diameter of these fibrils measured up to 300 nm whereas the fibrils present in the endometrium of virgin mice measured 40–68 nm.
子宫蜕膜瘤中的胶原蛋白合成和降解：黄体酮调节胶原酶活性。
DOI：
10.1016/s0174-173x(81)80003-9
发表时间：
1981
期刊：
Collagen and related research
影响因子：
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作者：
Jeffrey,JJ
通讯作者：
Jeffrey,JJ