Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis
Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis
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DOI：
10.1128/aac.42.5.1295
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发表时间：
1998-05-01
影响因子：
4.9
通讯作者：
Lerner, SA
中科院分区：
文献类型：
--
作者：
Alangaden, GJ;Kreiswirth, BN;Lerner, SA
在结核分枝杆菌（MTB）菌株ATCC 35827和13个对阿米卡星-卡那霉素耐药的MTB临床分离株（MIC，>128 μ g/ml）中鉴定了ns基因的A1400 G突变。高水平的交叉耐药性可能是由这种突变引起的，因为MTB具有单拷贝的rrs基因。另一种机制可能解释了两种突变体中高水平的阿米卡星-卡那霉素耐药性和四种临床分离株中较低水平的耐药性，所有分离株均缺乏A1400 G突变。
An A1400G mutation of the ns gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 mu g/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.