A multipronged approach to the identification and study of an important oncogene in GBM.
A multipronged approach to the identification and study of an important oncogene in GBM.
复制标题
DOI：
10.1016/j.ccr.2010.04.019
复制
发表时间：
2010-05
期刊：
影响因子：
50.3
通讯作者：
H. Kornblum
中科院分区：
文献类型：
--
作者：
H. Kornblum
在本期cancer Cell中，Zheng等人提供了PLAGL2在GBM中作为致癌基因的有力证据。他们证明PLAGL2抑制分化并促进持续的自我更新状态，至少部分原因是Wnt信号的激活。
In this issue ofCancer Cell, Zheng et al. provide strong evidence that PLAGL2 serves as an oncogene in GBM. They demonstrate that PLAGL2 inhibits differentiation and promotes a persistent, self-renewing state, at least in part because of activation of Wnt signaling.