Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements
Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements
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DOI：
10.1038/nn.2431
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发表时间：
2009-12-01
影响因子：
25
通讯作者：
Fukai, Tomoki
中科院分区：
文献类型：
--
作者：
Isomura, Yoshikazu;Harukuni, Rie;Fukai, Tomoki
运动皮层神经元在自主运动过程中的不同时间被激活。然而，在不同的皮质层中的兴奋性和抑制性神经元帮助组织自主运动的方式知之甚少。我们进行了积极行为大鼠的多细胞和多单位记录，发现兴奋性锥体细胞和抑制性快速尖峰中间神经元的时间和功能不同的激活。在整个皮质层中，锥体细胞被激活，以进行连续的运动阶段（例如，准备，启动和执行）。相比之下，快速尖峰的中间神经元，包括小清蛋白阳性篮状细胞，主要用于运动执行，锥体细胞产生命令样活动。因此，快速发放的中间神经元可能是通过平衡抑制或复发抑制进行命令成形的基础，而不是通过暂时交替的兴奋和抑制进行命令门控。此外，启动相关的锥体细胞通过假定的单突触连接兴奋相似和不同的功能类神经元。这表明，这些细胞可能暂时整合信息，以启动和协调自愿运动。
Motor cortex neurons are activated at different times during self-initiated voluntary movement. However, the manner in which excitatory and inhibitory neurons in distinct cortical layers help to organize voluntary movement is poorly understood. We carried out juxtacellular and multiunit recordings from actively behaving rats and found temporally and functionally distinct activations of excitatory pyramidal cells and inhibitory fast-spiking interneurons. Across cortical layers, pyramidal cells were activated diversely for sequential motor phases (for example, preparation, initiation and execution). In contrast, fast-spiking interneurons, including parvalbumin-positive basket cells, were recruited predominantly for motor execution, with pyramidal cells producing a command-like activity. Thus, fast-spiking interneurons may underlie command shaping by balanced inhibition or recurrent inhibition, rather than command gating by temporally alternating excitation and inhibition. Furthermore, initiation-associated pyramidal cells excited similar and different functional classes of neurons through putative monosynaptic connections. This suggests that these cells may temporally integrate information to initiate and coordinate voluntary movement.