Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.
Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.
复制标题
DOI：
10.1210/edrv.21.2.0395
复制
发表时间：
2000-04
影响因子：
20.3
通讯作者：
S. Manolagas
中科院分区：
文献类型：
--
作者：
S. Manolagas
成人骨骼通过由并列的破骨细胞和成骨细胞组成的临时细胞结构再生，并定期用新骨取代旧骨。在过去的十年中积累的大量证据表明，这两种高度专业化的细胞类型的发生速度以及它们的凋亡发生率对于维持骨骼的动态平衡是必不可少的；常见的代谢性骨骼疾病，如骨质疏松症，主要是由于这些细胞的出生或死亡的紊乱造成的。本文的目的有三个方面：1)综述细胞因子和激素等调节分子在破骨细胞和成骨细胞出生和凋亡中的作用和分子作用机制；2)综述骨细胞出生或死亡的变化在最常见的骨质疏松症发病机制中的作用；3)突出骨细胞出生和死亡的意义，以更好地了解目前和未来药物治疗骨质疏松症的作用机制和疗效。
The adult skeleton regenerates by temporary cellular structures that comprise teams of juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A considerable body of evidence accumulated during the last decade has shown that the rate of genesis of these two highly specialized cell types, as well as the prevalence of their apoptosis, is essential for the maintenance of bone homeostasis; and that common metabolic bone disorders such as osteoporosis result largely from a derangement in the birth or death of these cells. The purpose of this article is 3-fold: 1) to review the role and the molecular mechanism of action of regulatory molecules, such as cytokines and hormones, in osteoclast and osteoblast birth and apoptosis; 2) to review the evidence for the contribution of changes in bone cell birth or death to the pathogenesis of the most common forms of osteoporosis; and 3) to highlight the implications of bone cell birth and death for a better understanding of the mechanism of action and efficacy of present and future pharmacotherapeutic agents for osteoporosis.