Chronic L-tyrosine alters the locomotor activity and brain monoamine levels in Roborovskii hamsters
Chronic L-tyrosine alters the locomotor activity and brain monoamine levels in Roborovskii hamsters
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DOI：
10.1016/j.neulet.2010.10.077
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发表时间：
2011-01-13
影响因子：
2.5
通讯作者：
Furuse, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Kabuki, Yusuke;Shigemi, Kazutaka;Furuse, Mitsuhiro
Roborovskii仓鼠（Phodopus roborovskii）与同属的Djungarian仓鼠（Phodopus sungorus）相比，具有高运动活性（多动）和低多巴胺水平。为了阐明饮食中的L-酪氨酸在改善多动症状的功效，我们研究了长期给予L-酪氨酸（多巴胺的主要前体）对Roborovskii仓鼠的自发活动和脑单胺水平的影响。长期补充L-酪氨酸对旷场中的自发活动没有影响，但确实降低了家笼中的自发活动。酪氨酸增加多巴胺和去甲肾上腺素的周转率，并降低血清素周转率在大脑中。这些发现表明，长期喂养L-酪氨酸可能有效地改善多动症的迹象。(C)2010爱思唯尔爱尔兰有限公司版权所有。
The Roborovskii hamster (Phodopus roborovskii) has high locomotor activity (hyperactivity) and low dopamine levels in the brain compared with the congeneric Djungarian hamster (Phodopus sungorus). To clarify the efficacy of dietary L-tyrosine in ameliorating signs of hyperactivity, we investigated the effects of chronic administration of L-tyrosine, the primary precursor of dopamine, on locomotor activity and brain monoamine levels in Roborovskii hamsters. Chronic supplementation of L-tyrosine had no effect on locomotor activity in the open field, but did decrease locomotor activity in the home cage. Tyrosine increased dopamine and norepinephrine turnover rates and decreased in serotonin turnover rate in the brain. These findings suggest that long-term feeding of L-tyrosine may be effective in ameliorating signs of hyperactivity. (C) 2010 Elsevier Ireland Ltd. All rights reserved.