Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors.
Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors.
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1-氮杂双环-[3.2.1]辛烷的合成和生物学评价:新型多巴胺转运蛋白抑制剂。
DOI:
10.1016/s0960-894x(00)00308-5
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发表时间:
2000
影响因子:
2.7
通讯作者:
Kozikowski,AP
中科院分区:
文献类型:
--
作者:
Tamiz,AP;Smith,MP;Enyedy,I;Flippen-Anderson,J;Zhang,M;Johnson,KM;Kozikowski,AP
The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule.